Institute of Immunology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.
Nat Rev Immunol. 2017 Jan;17(1):30-48. doi: 10.1038/nri.2016.116. Epub 2016 Nov 28.
Dendritic cells (DCs) are potent and versatile antigen-presenting cells, and their ability to migrate is key for the initiation of protective pro-inflammatory as well as tolerogenic immune responses. Recent comprehensive studies have highlighted the importance of DC migration in the maintenance of immune surveillance and tissue homeostasis, and also in the pathogenesis of a range of diseases. In this Review, we summarize the anatomical, cellular and molecular factors that regulate the migration of different DC subsets in health and disease. In particular, we focus on new insights concerning the role of migratory DCs in the pathogenesis of diseases of the skin, intestine, lung, and brain, as well as in autoimmunity and atherosclerosis.
树突状细胞（DCs）是强有力且多功能的抗原呈递细胞，其迁移能力对于引发保护性炎症和耐受免疫反应至关重要。最近的综合研究强调了 DC 迁移在维持免疫监视和组织内稳态以及一系列疾病发病机制中的重要性。在这篇综述中，我们总结了调节不同 DC 亚群在健康和疾病中迁移的解剖学、细胞和分子因素。特别是，我们关注有关迁移性 DC 在皮肤、肠道、肺部和脑部疾病发病机制中的作用的新见解，以及在自身免疫和动脉粥样硬化中的作用。
