耐受性树突状细胞与自身免疫的调节
Modulation of tolerogenic dendritic cells and autoimmunity.
作者信息
Kim Sun Jung, Diamond Betty
机构信息
The Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, United States.
The Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, United States.
出版信息
Semin Cell Dev Biol. 2015 May;41:49-58. doi: 10.1016/j.semcdb.2014.04.020. Epub 2014 Apr 18.
Abstract
A key function of dendritic cells (DCs) is to induce either immune tolerance or immune activation. Many new DC subsets are being recognized, and it is now clear that each DC subset has a specialized function. For example, different DC subsets may express different cell surface molecules and respond differently to activation by secretion of a unique cytokine profile. Apart from intrinsic differences among DC subsets, various immune modulators in the microenvironment may influence DC function; inappropriate DC function is closely related to the development of immune disorders. The most exciting recent advance in DC biology is appreciation of human DC subsets. In this review, we discuss functionally different mouse and human DC subsets both in lymphoid organs and non-lymphoid organs, the molecules that regulate DC function, and the emerging understanding of the contribution of DCs to autoimmune diseases.
摘要
树突状细胞（DCs）的一个关键功能是诱导免疫耐受或免疫激活。许多新的DC亚群正在被识别，现在很清楚的是每个DC亚群都有特定的功能。例如，不同的DC亚群可能表达不同的细胞表面分子，并通过分泌独特的细胞因子谱对激活产生不同反应。除了DC亚群之间的内在差异外，微环境中的各种免疫调节剂可能会影响DC功能；不适当的DC功能与免疫紊乱的发展密切相关。DC生物学领域最近最令人兴奋的进展是对人类DC亚群的认识。在这篇综述中，我们讨论了在淋巴器官和非淋巴器官中功能不同的小鼠和人类DC亚群、调节DC功能的分子，以及对DCs在自身免疫性疾病中的作用的新认识。
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