Beetz R, Schulte-Wissermann H, Tröger J, Riedmiller H, Mannhardt W, Schofer O, Hohenfellner R
Department of Pediatrics, University of Mainz, FRG.
Eur Urol. 1989;16(5):366-71. doi: 10.1159/000471618.
With a mean follow-up of 10.8 years, 160 female and 29 male patients were investigated after successful correction of vesicoureterorenal reflux. All patients suffered from urinary tract infection (UTI) preoperatively, while postoperatively 42% of the patients developed further UTIs but with a significantly diminished rate of febrile infections. In comparison to a group of patients without postoperative UTI (n = 16), the uroepithelial cells of those patients with a high infection rate after reflux correction showed a significantly lower bacterial growth suppression (n = 37). Renal scars were found in 22% of the investigated renal units with operated ureters (n = 211). Of the preoperatively unscarred kidneys, 3.4% developed new scars during the observation period, mainly within the first 2 years after operation. In 7 (11.5%) of the 61 patients with renal scars, moderate arterial hypertension was found.
平均随访10.8年，对160例女性和29例男性患者在成功矫正膀胱输尿管反流后进行了调查。所有患者术前均患有尿路感染（UTI），而术后42%的患者再次发生UTI，但发热性感染率显著降低。与一组术后无UTI的患者（n = 16）相比，反流矫正后感染率高的患者的尿路上皮细胞显示出显著更低的细菌生长抑制（n = 37）。在接受手术的输尿管相关的211个被调查肾单位中，22%发现有肾瘢痕。术前无瘢痕的肾脏中，3.4%在观察期内出现了新的瘢痕，主要在术后头2年内。在61例有肾瘢痕的患者中，7例（11.5%）发现有中度动脉高血压。
