Ossorio-García Lidia, Jiménez-Gallo David, Rodríguez-Mateos María Eugenia, Arjona-Aguilera Cintia, Linares-Barrios Mario
Unidad de Gestión Clínica de Dermatología, Hospital Universitario Puerta del Mar, Cádiz, Spain.
Unidad de Gestión Clínica de Farmacia Hospitalaria, Hospital Universitario Puerta del Mar, Cádiz, Spain.
Dermatol Ther. 2017 Mar;30(2). doi: 10.1111/dth.12451. Epub 2016 Nov 28.
Prurigo nodularis (PN) is an intensely pruriginous dermatological disorder whose treatment is challenging for dermatologists. It is characterized by eruptions of papules and hyperkeratotic nodules, some of which are eroded, on the extensor surfaces of the limbs. The most commonly used treatments for this condition are oral antihistamines and topical or systemic steroids. Thalidomide is an effective treatment option in cases of recalcitrant PN; however, its most frequent adverse effect is neurotoxicity, which often results in its discontinuation. Lenalidomide is an analogue of thalidomide that is more powerful and associated with less neurotoxicity than thalidomide. We report the third case of PN treated with lenalidomide, which involved a patient who was refractory to thalidomide. Lenalidomide may be a more effective treatment for PN than thalidomide and has a more favorable side effects profile than its counterpart.
结节性痒疹（PN）是一种瘙痒剧烈的皮肤病，其治疗对皮肤科医生来说具有挑战性。它的特征是在四肢伸侧出现丘疹和角化过度的结节，其中一些有糜烂。针对这种病症最常用的治疗方法是口服抗组胺药以及外用或全身性类固醇。沙利度胺是治疗顽固性PN的一种有效选择；然而，其最常见的不良反应是神经毒性，这常常导致停药。来那度胺是沙利度胺的类似物，比沙利度胺效力更强且神经毒性更小。我们报告了第三例用 来那度胺治疗的PN病例，该患者对沙利度胺耐药。来那度胺可能是比沙利度胺更有效的PN治疗药物，并且副作用比沙利度胺更少。
