中国肺癌患者人格特征的初步研究：神经降压素受体 1 多态性的修饰作用。
Preliminary study of personality traits in Chinese lung cancer patients: Modification by neurotensin receptor 1 polymorphisms.
机构信息
Center for Mental Health & College of Humanities and Law, Yanshan University, Qinhuangdao, China.
Center for Mental Health, China Medical University, Shenyang, China.
出版信息
Asia Pac Psychiatry. 2017 Dec;9(4). doi: 10.1111/appy.12268. Epub 2016 Nov 28.
This study recruited 148 lung cancer patients and 157 healthy Chinese individuals to evaluate the personality traits of Chinese lung cancer patients using the Tridimensional Personality Questionnaire and to investigate the associations between these traits and the rs6090453C/G and rs6011914C/G polymorphisms of the neurotensin receptor 1 gene. The results demonstrated significant differences in the Tridimensional Personality Questionnaire total and subscale scores between the 2 groups. Significant differences were found in the reward dependence 2 (RD2) score between the rs6090453C/G genotypes and in the total harm avoidance (HA), HA1, HA2, HA4, and RD2 scores between the rs6011914C/G genotypes. Thus, patients with lung cancer have specific personality traits, and variations in the neurotensin receptor 1 gene may be involved in the biological mechanisms of the HA and RD personality traits.
本研究招募了 148 例肺癌患者和 157 例健康中国个体，使用三维人格问卷评估中国肺癌患者的人格特征，并探讨这些特征与神经降压素受体 1 基因 rs6090453C/G 和 rs6011914C/G 多态性之间的关系。结果表明，两组间三维人格问卷总分和分量表评分存在显著差异。rs6090453C/G 基因型间的奖赏依赖 2（RD2）评分存在显著差异，rs6011914C/G 基因型间的总回避（HA）、HA1、HA2、HA4 和 RD2 评分存在显著差异。因此，肺癌患者具有特定的人格特征，神经降压素受体 1 基因的变异可能参与 HA 和 RD 人格特质的生物学机制。
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