Flad H D, Loppnow H, Feist W, Wang M H, Brade H, Kusumoto S, Rietschel E T, Ulmer A J
Forschungsinstitut Borstel, FRG.
Lymphokine Res. 1989 Fall;8(3):235-8.
Minimal concentration ranges of lipopolysaccharides, natural and synthetic lipid As, and partial structures were established for the induction of release of IL-1 and TNF from human MNC. LPS was more potent than lipid A. Partial structures of lipid A lacking nonhydroxylated fatty acids were inactive, but in combination with LPS or lipid A exhibited time-dependent synergistic or antagonistic effects.
确定了脂多糖、天然和合成类脂A及其部分结构诱导人单核细胞释放白细胞介素-1（IL-1）和肿瘤坏死因子（TNF）的最低浓度范围。脂多糖比类脂A更有效。缺乏非羟基化脂肪酸的类脂A部分结构无活性，但与脂多糖或类脂A联合使用时表现出时间依赖性的协同或拮抗作用。
