Özyol Pelin, Özyol Erhan, Karalezli Aylin
a Department of Ophthalmology , Muğla Sıtkı Koçman University Faculty of Medicine , Muğla , Turkey.
Semin Ophthalmol. 2018;33(3):320-324. doi: 10.1080/08820538.2016.1238096. Epub 2016 Nov 28.
To examine the effect of a single dose of artificial tear administration on automated visual field (VF) testing in patients with glaucoma and dry eye syndrome.
A total of 35 patients with primary open-angle glaucoma experienced in VF testing with symptoms of dry eye were enrolled in this study. At the first visit, standard VF testing was performed. At the second and third visits with an interval of one week, while the left eyes served as control, one drop of artificial tear was administered to each patient's right eye, and then VF testing was performed again. The reliability parameters, VF indices, number of depressed points at probability levels of pattern deviation plots, and test times were compared between visits.
No significant difference was observed in any VF testing parameters of control eyes (P>0.05). In artificial tear administered eyes, significant improvement was observed in test duration, mean deviation, and the number of depressed points at probability levels (P˂0.5%, P˂1%, P˂2) of pattern deviation plots (P˂0.05). The post-hoc test revealed that artificial tear administration elicited an improvement in test duration, mean deviation, and the number of depressed points at probability levels (P˂0.5%, P˂1%, P˂2%) of pattern deviation plots from first visit to second and third visits (P˂0.01, for all comparisons). The intraclass correlation coefficient for the three VF test indices was found to be between 0.735 and 0.85 (P<0.001, for all).
A single dose of artificial tear administration immediately before VF testing seems to improve test results and decrease test time.
研究单剂量人工泪液给药对青光眼和干眼综合征患者自动视野（VF）检测的影响。
本研究共纳入35例有干眼症状且熟悉VF检测的原发性开角型青光眼患者。首次就诊时进行标准VF检测。在间隔一周的第二次和第三次就诊时，左眼作为对照，给每位患者的右眼滴一滴人工泪液，然后再次进行VF检测。比较各次就诊之间的可靠性参数、VF指数、模式偏差图概率水平下的压低点数和检测时间。
对照眼的任何VF检测参数均未观察到显著差异（P>0.05）。在滴入人工泪液的眼中，检测持续时间、平均偏差以及模式偏差图概率水平（P˂0.5%、P˂1%、P˂2）下的压低点数均有显著改善（P˂0.05）。事后检验显示，从首次就诊到第二次和第三次就诊，滴入人工泪液使检测持续时间、平均偏差以及模式偏差图概率水平（P˂0.5%、P˂1%、P˂2%）下的压低点数得到改善（所有比较，P˂0.01）。发现三个VF检测指数的组内相关系数在0.735至0.85之间（所有均P<0.001）。
在VF检测前立即给予单剂量人工泪液似乎可改善检测结果并缩短检测时间。
