银纳米颗粒增强替莫唑胺对人胶质瘤细胞的敏感性。
Silver nanoparticles enhance the sensitivity of temozolomide on human glioma cells.
作者信息
Liang Ping, Shi Hongming, Zhu Weiguo, Gui Qunfeng, Xu Ya, Meng Jianfeng, Guo Xiaoyuan, Gong Zhuang, Chen Huaqun
机构信息
Department of Neurology, Yancheng Hospital Affiliated to Southeast University, Yancheng, 224001, China.
Department of Neurology, Zhongda Hospital Affiliated to Southeast University, Nanjing, 210009, China.
出版信息
Oncotarget. 2017 Jan 31;8(5):7533-7539. doi: 10.18632/oncotarget.13503.
Glioblastoma multiforme (GBM) continues to be associated with a dismal prognosis despite aggressive treatment. Significant efforts are being made to develop new nanotechnology-based therapeutic and diagnostic agents. Nanoparticles can act directly on cancer cells or as drug carriers to enhance the cancer therapeutic effect. In this study, we investigated the effect of silver nanoparticles (AgNPs) on human glioma U251 cells and its role in the combinational use with Temozolomide (TMZ), an imidazotetrazine derivative of the alkylating agent dacarbazine, against glioma cells. AgNPs were synthesized in the sodium citrate system and the mean size were 26 nm in diameter. The AgNP particles showed dose-dependent cytotoxicity on U251 cells. They also showed the ability to enhance the drug-sensitivity of TMZ on U251 cells. Our results revealed that AgNPs could have a potential application in enhancing chemotherapy for glioma.
尽管进行了积极治疗，多形性胶质母细胞瘤（GBM）的预后仍然很差。人们正在大力研发基于纳米技术的新型治疗和诊断药物。纳米颗粒可以直接作用于癌细胞，或作为药物载体来增强癌症治疗效果。在本研究中，我们研究了银纳米颗粒（AgNPs）对人胶质瘤U251细胞的影响，以及其在与替莫唑胺（TMZ）联合使用时对胶质瘤细胞的作用。替莫唑胺是烷化剂达卡巴嗪的咪唑并四嗪衍生物。AgNPs在柠檬酸钠体系中合成，平均直径为26 nm。AgNP颗粒对U251细胞表现出剂量依赖性细胞毒性。它们还显示出增强TMZ对U251细胞药物敏感性的能力。我们的结果表明，AgNPs在增强胶质瘤化疗方面可能具有潜在应用价值。
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