巴西人类着色芽生菌病病原体的分子流行病学及两个新物种的描述
Molecular Epidemiology of Agents of Human Chromoblastomycosis in Brazil with the Description of Two Novel Species.
作者信息
Gomes Renata R, Vicente Vania A, Azevedo Conceição M P S de, Salgado Claudio G, da Silva Moises B, Queiroz-Telles Flávio, Marques Sirlei G, Santos Daniel W C L, de Andrade Tania S, Takagi Elizabeth H, Cruz Katia S, Fornari Gheniffer, Hahn Rosane C, Scroferneker Maria L, Caligine Rachel B, Ramirez-Castrillon Mauricio, de Araújo Daniella P, Heidrich Daiane, Colombo Arnaldo L, de Hoog G S
机构信息
Microbiology, Parasitology and Pathology Post-graduation Program, Department of Basic Pathology, Federal University of Paraná, Curitiba, PR, Brazil.
Department of Biological Science, State University of Parana/ Campus Paranaguá, Paranaguá, PR, Brazil.
出版信息
PLoS Negl Trop Dis. 2016 Nov 28;10(11):e0005102. doi: 10.1371/journal.pntd.0005102. eCollection 2016 Nov.
The human mutilating disease chromoblastomycosis is caused by melanized members of the order Chaetothyriales. To assess population diversity among 123 clinical strains of agents of the disease in Brazil we applied sequencing of the rDNA internal transcribed spacer region, and partial cell division cycle and β-tubulin genes. Strains studied were limited to three clusters divided over the single family Herpotrichiellaceae known to comprise agents of the disease. A Fonsecaea cluster contained the most important agents, among which F. pedrosoi was prevalent with 80% of the total set of strains, followed by 13% for F. monophora, 3% for F. nubica, and a single isolate of F. pugnacius. Additional agents, among which two novel species, were located among members of the genus Rhinocladiella and Cyphellophora, with frequencies of 3% and 1%, respectively.
人类致残性疾病着色芽生菌病由座囊菌纲的黑化菌引起。为评估巴西123株该病病原体临床菌株的群体多样性，我们对核糖体DNA内转录间隔区、部分细胞分裂周期基因和β-微管蛋白基因进行了测序。所研究的菌株局限于已知包含该病病原体的单一家族——暗梗节孢科中的三个簇。一个瓶霉属簇包含了最重要的病原体，其中裴氏瓶霉最为常见，占菌株总数的80%，其次是单孢瓶霉，占13%，努比亚瓶霉占3%，还有一株好斗瓶霉。其他病原体，其中包括两个新物种，分别位于枝孢瓶霉属和瓶杯霉属成员中，频率分别为3%和1%。
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