使用熔合闪烁体对PC12细胞摄取氚化胸腺嘧啶核苷过程中氚放射性分布进行闪烁成像。

Scintillation imaging of tritium radioactivity distribution during tritiated thymidine uptake by PC12 cells using a melt-on scintillator.

作者信息

Irikura Namiko, Miyoshi Hirokazu, Shinohara Yasuo

机构信息

Institute of Biomedical Science, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan; Graduate School of Pharmaceutical Sciences, Tokushima University, 1-78 Shomachi, Tokushima 770-8505, Japan.

Radioisotope Research Center, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.

出版信息

Appl Radiat Isot. 2017 Feb;120:11-16. doi: 10.1016/j.apradiso.2016.11.003. Epub 2016 Nov 15.

DOI:10.1016/j.apradiso.2016.11.003

PMID:27894045

Abstract

A scintillation image of tritium fixed in a melt-on scintillator was obtained using a charged-coupled device (CCD) imager, and a linear relationship was observed between the intensity of the scintillation image and the radioactivity of tritium. In a [H]thymidine uptake experiment, a linear correlation between the intensity of the CCD image and the dilution ratio of cells was confirmed. Scintillation imaging has the potential for use in direct observation of tritium radioactivity distribution.

摘要

使用电荷耦合器件（CCD）成像仪获得了固定在熔凝闪烁体中的氚的闪烁图像，并观察到闪烁图像强度与氚放射性之间存在线性关系。在[H]胸腺嘧啶核苷摄取实验中，证实了CCD图像强度与细胞稀释率之间存在线性相关性。闪烁成像具有直接观察氚放射性分布的潜力。