Dubois A, Rossi J F, Double C M, Pignodel C, Roumieux J L, Lafontaine J S, Lallemant J G
Rev Laryngol Otol Rhinol (Bord). 1989;110(2):151-5.
Midline granuloma includes diverse clinicopathological entities, such as Wegener granulomatosis, polymorphic reticulosis, lethal midline granuloma and conventional malignant lymphoma of the nose usually of B-cell origin. The authors describe five patients with LMG clinically and pathologically typical. Using an extensive panel of monoclonal antibodies, they demonstrate an "activate" T-cell phenotype observed on the initial lesion of the face in one patient, similar to that found in two patients with LMG but studied after dissemination in peripheral T-cell lymphoma. Furthermore, many atypical cells were found in LMG, and stained with the Ki-67 monoclonal antibody, a marker of proliferating cells. These findings support the view that LMG is closely related to T-cell malignancies. Two of them were treated with recombinant Interferon alpha 2a followed by a response rapidly objective. Immunohistologic studies are very important for confirming the T-cell origin of such a disease and for selecting patients to be treated with Interferon alpha.
中线肉芽肿包括多种临床病理实体，如韦格纳肉芽肿、多形性网状细胞增生症、致死性中线肉芽肿以及通常起源于B细胞的鼻部传统恶性淋巴瘤。作者描述了5例临床和病理表现典型的致死性中线肉芽肿患者。他们使用大量单克隆抗体，在1例患者面部的初始病变中发现了一种“活化”T细胞表型，类似于2例致死性中线肉芽肿患者在外周T细胞淋巴瘤播散后所发现的表型。此外，在致死性中线肉芽肿中发现了许多非典型细胞，并用增殖细胞标志物Ki-67单克隆抗体进行了染色。这些发现支持了致死性中线肉芽肿与T细胞恶性肿瘤密切相关的观点。其中2例患者接受重组干扰素α 2a治疗后迅速出现客观反应。免疫组织学研究对于证实此类疾病的T细胞起源以及选择接受干扰素α治疗的患者非常重要。
