Islam Nasir Irfan Ul, Ashraf Muhammad Ijaz, Ahmed Nouman, Shah Muhammad Fahd, Pirzada Muhammad Taqi, Syed Amir Ali, Qazi Abid Quddus
Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.
General Surgery, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.
J Pak Med Assoc. 2016 Oct;66(Suppl 3)(10):S119-S121.
Germ Cell Tumours (GCTs) are rare tumours. Generally 80% are benign and 20% malignant with a bimodal age distribution. The retrospective study was conducted at Shaukat Khanum Cancer Hospital, Lahore, Pakistan, and comprised all paediatric patients below 18 years of age who received treatment for histology-proven GCT from 2006 to 2014. Of the 207 patients, 98(42.3%) were males and 109(52.7%) were females. The most common GCT was yolk sac tumour in 90(43.5%) children followed by mixed GCT in 40(19.3%) and dysgerminoma in 34(16.4%). Gonads were most commonly involved in 165(79.7%) patients with metastasis in 24(11.6%) at presentation and recurrence in 26(12.5%) patients. Overall, 133(64.3%) patients are well and followed up at regular intervals and 55(26.5%) have been lost to follow-up with an expected overall 5-year median survival of 45%. Despite the distinct clinical profile of paediatric GCT, survival can be improved by early diagnosis, regimented treatment according to set guidelines, protocols and by improving follow-up.
生殖细胞肿瘤（GCTs）是罕见肿瘤。一般来说，80%为良性，20%为恶性，具有双峰年龄分布。这项回顾性研究在巴基斯坦拉合尔的绍卡特·汗姆癌症医院开展，纳入了2006年至2014年期间所有接受组织学确诊的GCT治疗的18岁以下儿科患者。207例患者中，98例（42.3%）为男性，109例（52.7%）为女性。最常见的GCT是卵黄囊瘤，90例（43.5%）儿童患病，其次是混合性GCT，40例（19.3%），无性细胞瘤34例（16.4%）。性腺最常受累，165例（79.7%）患者初诊时有24例（11.6%）发生转移，26例（12.5%）患者复发。总体而言，133例（64.3%）患者情况良好并定期接受随访，55例（26.5%）失访，预计总体5年中位生存率为45%。尽管儿科GCT有独特的临床特征，但通过早期诊断、按照既定指南和方案进行规范化治疗以及改善随访，生存率可以提高。
