• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一名67岁尿道腺癌女性患者通过外照射放疗和图像引导自适应组织间近距离放疗成功治愈。

Successful treatment of a 67-year-old woman with urethral adenocarcinoma with the use of external beam radiotherapy and image guided adaptive interstitial brachytherapy.

作者信息

Mujkanovic Jasmin, Tanderup Kari, Agerbæk Mads, Bisgaard Ulla, Høyer Søren, Lindegaard Jacob Christian, Fokdal Lars

机构信息

Department of Oncology.

Department of Urology.

出版信息

J Contemp Brachytherapy. 2016 Oct;8(5):434-437. doi: 10.5114/jcb.2016.63461. Epub 2016 Nov 7.

DOI:10.5114/jcb.2016.63461
PMID:27895686
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5116457/
Abstract

Primary urethral cancer (PUC) is a very rare disease. This case report illustrates a successful treatment approach of a 67-year-old woman with a urethral adenocarcinoma selected for an organ preserving treatment with external beam radiotherapy (EBRT) and interstitial brachytherapy (BT) boost, using the GEC-ESTRO target concept originally designed for locally advanced cervical cancer (LACC). Treatment included EBRT with 45 Gy in 25 fractions followed by image guided adaptive interstitial BT (IGABT) with a pulsed-dose-rate (PDR) BT boost with 30 Gy in 50 hourly pulses. The D for CTV was 79.1 Gy in EQD2. At 24 months follow-up, the patient was recurrence free and without treatment related side effects.

摘要

原发性尿道癌（PUC）是一种非常罕见的疾病。本病例报告展示了一种成功的治疗方法，该方法用于一名67岁患有尿道腺癌的女性，采用了最初为局部晚期宫颈癌（LACC）设计的GEC-ESTRO靶区概念，选择了外照射放疗（EBRT）和组织间插植近距离放疗（BT）增敏的器官保留治疗。治疗包括25次分割给予45 Gy的EBRT，随后进行图像引导的自适应组织间插植近距离放疗（IGABT），采用脉冲剂量率（PDR）近距离放疗增敏，50个小时脉冲给予30 Gy。CTV的等效均匀剂量（EQD2）为79.1 Gy。随访24个月时，患者无复发且无治疗相关副作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcad/5116457/a9a7b7f54859/JCB-8-28658-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcad/5116457/99120c4a75ef/JCB-8-28658-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcad/5116457/a9a7b7f54859/JCB-8-28658-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcad/5116457/99120c4a75ef/JCB-8-28658-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcad/5116457/a9a7b7f54859/JCB-8-28658-g002.jpg

相似文献

1
Successful treatment of a 67-year-old woman with urethral adenocarcinoma with the use of external beam radiotherapy and image guided adaptive interstitial brachytherapy.一名67岁尿道腺癌女性患者通过外照射放疗和图像引导自适应组织间近距离放疗成功治愈。
J Contemp Brachytherapy. 2016 Oct;8(5):434-437. doi: 10.5114/jcb.2016.63461. Epub 2016 Nov 7.
2
Image and laparoscopic guided interstitial brachytherapy for locally advanced primary or recurrent gynaecological cancer using the adaptive GEC ESTRO target concept.图像引导和腹腔镜引导的局部晚期原发性或复发性妇科癌症间质近距离放疗，使用适应性 GEC ESTRO 靶区概念。
Radiother Oncol. 2011 Sep;100(3):473-9. doi: 10.1016/j.radonc.2011.08.016. Epub 2011 Sep 15.
3
MRI-guided adaptive brachytherapy for locally advanced cervix cancer: Treatment outcomes from a single institution in Hong Kong.MRI引导下的适形近距离放射治疗用于局部晚期宫颈癌：香港一家机构的治疗结果
Brachytherapy. 2019 Mar-Apr;18(2):171-179. doi: 10.1016/j.brachy.2018.11.007. Epub 2018 Dec 21.
4
Parametrial boosting in locally advanced cervical cancer: combined intracavitary/interstitial brachytherapy vs. intracavitary brachytherapy plus external beam radiotherapy.局部晚期宫颈癌的宫旁组织增敏：腔内/组织间插植近距离放疗联合与腔内近距离放疗加体外照射放疗的比较
Brachytherapy. 2015 Jan-Feb;14(1):23-8. doi: 10.1016/j.brachy.2014.09.010. Epub 2014 Nov 8.
5
Clinical Outcomes of MRI-Guided Adaptive Brachytherapy for Each Fraction in Locally Advanced Cervical Cancer: A Single Institution Experience.局部晚期宫颈癌每次分次MRI引导下自适应近距离放疗的临床结果：单机构经验
Front Oncol. 2022 Mar 17;12:841980. doi: 10.3389/fonc.2022.841980. eCollection 2022.
6
Toward four-dimensional image-guided adaptive brachytherapy in locally recurrent endometrial cancer.迈向局部复发性子宫内膜癌的四维图像引导自适应近距离放射治疗。
Brachytherapy. 2014 Nov-Dec;13(6):554-61. doi: 10.1016/j.brachy.2014.06.004. Epub 2014 Jul 20.
7
MRI-guided adaptive radiotherapy in locally advanced cervical cancer from a Nordic perspective.MRI 引导自适应放疗在局部晚期宫颈癌治疗中的北欧视角。
Acta Oncol. 2013 Oct;52(7):1510-9. doi: 10.3109/0284186X.2013.818253. Epub 2013 Aug 21.
8
Long term experience with 3D image guided brachytherapy and clinical outcome in cervical cancer patients.宫颈癌患者3D图像引导近距离放射治疗的长期经验及临床结果
Radiother Oncol. 2016 Sep;120(3):447-454. doi: 10.1016/j.radonc.2016.04.016. Epub 2016 May 2.
9
Effect of tumor dose, volume and overall treatment time on local control after radiochemotherapy including MRI guided brachytherapy of locally advanced cervical cancer.肿瘤剂量、体积及总治疗时间对局部晚期宫颈癌放化疗（包括MRI引导下近距离放疗）后局部控制的影响。
Radiother Oncol. 2016 Sep;120(3):441-446. doi: 10.1016/j.radonc.2016.05.014. Epub 2016 Jun 24.
10
Clinical outcomes of definitive chemoradiation followed by intracavitary pulsed-dose rate image-guided adaptive brachytherapy in locally advanced cervical cancer.局部晚期宫颈癌患者先行根治性放化疗，随后行腔内脉冲剂量率图像引导自适应近距离放疗的临床疗效
Gynecol Oncol. 2015 Nov;139(2):288-94. doi: 10.1016/j.ygyno.2015.09.008. Epub 2015 Sep 11.

引用本文的文献

1
Progress in the treatment of urethral adenocarcinoma.尿道腺癌的治疗进展
J Cancer Res Clin Oncol. 2023 Jun;149(6):2693-2698. doi: 10.1007/s00432-022-04481-5. Epub 2022 Nov 21.

本文引用的文献

1
High-dose-rate interstitial brachytherapy for female peri-urethral cancer.高剂量率组织间近距离放射疗法治疗女性尿道周围癌
J Contemp Brachytherapy. 2016 Feb;8(1):41-7. doi: 10.5114/jcb.2016.57461. Epub 2016 Jan 27.
2
Outcomes for patients with cervical cancer treated with extended-field intensity-modulated radiation therapy and concurrent cisplatin.接受扩展野调强放疗并同期顺铂化疗的宫颈癌患者的治疗结果。
Int J Gynecol Cancer. 2013 Jan;23(1):119-25. doi: 10.1097/IGC.0b013e3182749114.
3
Incidence and survival of rare urogenital cancers in Europe.
欧洲罕见泌尿生殖系统癌症的发病率和生存率。
Eur J Cancer. 2012 Mar;48(4):456-64. doi: 10.1016/j.ejca.2011.10.031. Epub 2011 Nov 24.
4
Image and laparoscopic guided interstitial brachytherapy for locally advanced primary or recurrent gynaecological cancer using the adaptive GEC ESTRO target concept.图像引导和腹腔镜引导的局部晚期原发性或复发性妇科癌症间质近距离放疗，使用适应性 GEC ESTRO 靶区概念。
Radiother Oncol. 2011 Sep;100(3):473-9. doi: 10.1016/j.radonc.2011.08.016. Epub 2011 Sep 15.
5
Carcinoma of the urethra: radiation oncology.尿道癌：放射肿瘤学。
Urol Clin North Am. 2010 Aug;37(3):459-66. doi: 10.1016/j.ucl.2010.04.007. Epub 2010 Jun 17.
6
Pelvic exenteration: ten-year experience at the European Institute of Oncology in Milan.盆腔脏器切除术：米兰欧洲肿瘤研究所的十年经验
Gynecol Oncol. 2009 Jul;114(1):64-8. doi: 10.1016/j.ygyno.2009.03.029. Epub 2009 May 2.
7
Incidence of primary urethral carcinoma in the United States.美国原发性尿道癌的发病率。
Urology. 2006 Dec;68(6):1164-8. doi: 10.1016/j.urology.2006.08.1057. Epub 2006 Dec 4.
8
Recommendations from gynaecological (GYN) GEC ESTRO working group (II): concepts and terms in 3D image-based treatment planning in cervix cancer brachytherapy-3D dose volume parameters and aspects of 3D image-based anatomy, radiation physics, radiobiology.妇科（GYN）GEC ESTRO工作组（II）的建议：宫颈癌近距离治疗基于三维图像的治疗计划中的概念和术语——三维剂量体积参数以及基于三维图像的解剖学、放射物理学、放射生物学方面
Radiother Oncol. 2006 Jan;78(1):67-77. doi: 10.1016/j.radonc.2005.11.014. Epub 2006 Jan 5.
9
Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group (I): concepts and terms in 3D image based 3D treatment planning in cervix cancer brachytherapy with emphasis on MRI assessment of GTV and CTV.妇科（GYN）GEC-ESTRO工作组（I）的建议：基于3D图像的宫颈癌近距离治疗三维治疗计划中的概念和术语，重点是GTV和CTV的MRI评估
Radiother Oncol. 2005 Mar;74(3):235-45. doi: 10.1016/j.radonc.2004.12.015.
10
Brachytherapy for cancer of the female urethra.女性尿道癌的近距离放射治疗
Semin Surg Oncol. 1997 May-Jun;13(3):208-14. doi: 10.1002/(sici)1098-2388(199705/06)13:3<208::aid-ssu9>3.0.co;2-b.