Yao Gang
Department of Radiology, Zaozhuang Municipal Hospital, Zaozhuang, Shandong 277100, P.R. China.
Oncol Lett. 2016 Nov;12(5):3933-3935. doi: 10.3892/ol.2016.5133. Epub 2016 Sep 14.
The aim of the present study was to examine the value of window technique in qualitative diagnosis of the ground glass opacities (GGO) in patients with non-small cell pulmonary cancer. A total of 124 clinically suspected pulmonary cancer patients were analyzed retrospectively. The lesions were affirmed by puncture biopsy, and were GGO on pulmonary window while were invisible on mediastinal window. Sixty-four multi-detector spiral computed tomography with the window width and window level of 1,500 Hounsfield units (HU) and -450 HU on pulmonary window, while the window width and window level of 400 and 40 HU on mediastinal window, was used in the study. The window adjustment technique was used to analyze the window width and window level of lesion on pulmonary window and mediastinal window, for searching invisible threshold on 3-megapixel medical displays. The diagnostic accuracy and the cut-off value were compared on receiver operating characteristic (ROC) curve. The results showed that the window width and window level on pulmonary window and mediastinal window of malignant lesions were significantly less than those of benign ones (P<0.05). The cut-off value on pulmonary window was the window width and window level of 1,300 and -220 HU, the area under the ROC was 0.830 [sensitivity was 72.5%, specificity was 84.3%; 95% confidence interval (CI), 0.712-0.945]. The cut-off value on mediastinal window was the window width and window level of 360 and 30 HU, and the area under the ROC was 0.623 (was 62.0%, specificity was 55.7%; 95% CI, 0.541-0.745). In conclusion, the window technique has high sensitivity and accuracy in qualitative diagnosis of the GGO.
本研究旨在探讨窗技术在非小细胞肺癌患者磨玻璃影（GGO）定性诊断中的价值。回顾性分析124例临床疑似肺癌患者。病变经穿刺活检确诊，在肺窗上为GGO，而在纵隔窗上不可见。本研究使用了64排螺旋计算机断层扫描，肺窗的窗宽和窗位分别为1500亨氏单位（HU）和-450 HU，纵隔窗的窗宽和窗位分别为400和40 HU。采用窗调整技术分析病变在肺窗和纵隔窗上的窗宽和窗位，以寻找在300万像素医学显示器上不可见的阈值。在受试者工作特征（ROC）曲线上比较诊断准确性和截断值。结果显示，恶性病变在肺窗和纵隔窗上的窗宽和窗位明显小于良性病变（P<0.05）。肺窗的截断值为窗宽1300 HU和窗位-220 HU，ROC曲线下面积为0.830[灵敏度为72.5%，特异度为84.3%；95%置信区间（CI），0.712-0.945]。纵隔窗的截断值为窗宽360 HU和窗位30 HU，ROC曲线下面积为0.623（灵敏度为62.0%，特异度为55.7%；95%CI，0.541-0.745）。总之，窗技术在GGO的定性诊断中具有较高的灵敏度和准确性。
