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[Clinical effect of hemoperfusion combined with hemodialysis in treatment of severe organophosphate pesticide poisoning].血液灌流联合血液透析治疗重度有机磷农药中毒的临床疗效
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2014 Dec;32(12):928-30.
2
Percutaneous absorption and distribution of organophosphates (chlorpyrifos and dichlorvos) following dermal exposure and decontamination scenarios using in vitro human skin model.使用体外人皮肤模型,研究在皮肤暴露和去污情况下有机磷酸酯(毒死蜱和敌敌畏)的经皮吸收和分布。
Toxicol Lett. 2014 Aug 17;229(1):66-72. doi: 10.1016/j.toxlet.2014.06.008. Epub 2014 Jun 6.
3
Guidelines on the use of therapeutic apheresis in clinical practice-evidence-based approach from the Writing Committee of the American Society for Apheresis: the sixth special issue.美国血液分离协会写作委员会制定的临床实践中治疗性血液分离术使用指南:循证方法,第六期特刊。
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Effectiveness of therapeutic plasma exchange in patients with intermediate syndrome due to organophosphate intoxication.治疗性血浆置换治疗有机磷中毒中间综合征的疗效。
Am J Emerg Med. 2013 Jun;31(6):953-7. doi: 10.1016/j.ajem.2013.03.016. Epub 2013 May 17.
5
Medications in patients treated with therapeutic plasma exchange: prescription dosage, timing, and drug overdose.接受治疗性血浆置换的患者的用药:处方剂量、用药时间及药物过量
Semin Dial. 2012 Mar-Apr;25(2):176-89. doi: 10.1111/j.1525-139X.2011.01030.x. Epub 2012 Feb 9.
6
Defense against dermal exposures is only skin deep: significantly increased penetration through slightly damaged skin.对皮肤暴露的防御只是表面的:通过轻微受损皮肤的渗透会显著增加。
Arch Dermatol Res. 2007 Nov;299(9):423-31. doi: 10.1007/s00403-007-0788-z. Epub 2007 Sep 20.
7
The effects of fresh frozen plasma on cholinesterase levels and outcomes in patients with organophosphate poisoning.新鲜冰冻血浆对有机磷中毒患者胆碱酯酶水平及预后的影响。
J Toxicol Clin Toxicol. 2004;42(5):617-23. doi: 10.1081/clt-200026967.
8
The effect of plasmapheresis on plasma cholinesterase levels in a patient with organophosphate poisoning.
Hum Exp Toxicol. 2004 Jul;23(7):365-8. doi: 10.1191/0960327104ht462cr.
9
Current applications of plasmapheresis in clinical toxicology.血浆置换在临床毒理学中的当前应用。
Nephrol Dial Transplant. 2003 Jul;18 Suppl 5:v56-8. doi: 10.1093/ndt/gfg1049.
10
Therapeutic plasma exchange in the intensive care setting.重症监护环境下的治疗性血浆置换
Ther Apher. 2001 Oct;5(5):351-7. doi: 10.1046/j.1526-0968.2001.00383.x.

血浆置换在有机磷中毒中的应用:一例报告。

Utilization of plasmapheresis for organophosphate intoxication: A case report.

作者信息

Disel Nezihat Rana, Acikalin Ayca, Kekec Zeynep, Sebe Ahmet

机构信息

Cukurova University, Faculty of Medicine, Department of Emergency Medicine, Adana, Turkey.

出版信息

Turk J Emerg Med. 2016 May 7;16(2):69-71. doi: 10.1016/j.tjem.2015.06.003. eCollection 2016 Jun.

DOI:10.1016/j.tjem.2015.06.003
PMID:27896325
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5121276/
Abstract

Organophosphate (OP) compounds are extremely toxic chemicals that may be absorbed via skin, conjunctiva, gastrointestinal and respiratory systems. Treatment of OP poisoning is a critical and aggressive process which includes decontamination, antidote administration (atropin and oximes), mechanical ventilation support and extracorporeal elimination procedures if needed. Here we present a young female patient who was unintentionally poisoned by an OP (trichlorfon) after using it to moisture her skin. The importance of this patient is the dermal disease that makes her unprotective to dermal exposure of chemicals and application of plasmapheresis to treat her poisoning.

摘要

有机磷酸酯(OP)化合物是剧毒化学品,可通过皮肤、结膜、胃肠道和呼吸系统吸收。OP中毒的治疗是一个关键且积极的过程,包括去污、使用解毒剂(阿托品和肟类)、机械通气支持以及必要时的体外清除程序。在此,我们介绍一名年轻女性患者,她在使用敌百虫(一种OP)滋润皮肤后意外中毒。该患者的特殊之处在于其皮肤病使她对皮肤接触化学品缺乏防护能力,以及采用血浆置换术治疗其中毒情况。