Dimsdale J E, O'Connor D, Ziegler M, Mills P
Department of Psychiatry, University of California, San Diego.
Neuropsychopharmacology. 1989 Sep;2(3):237-40. doi: 10.1016/0893-133x(89)90027-4.
Plasma chromogranin A, norepinephrine, epinephrine, blood pressure, and heart rate were examined in 51 unmedicated volunteers at rest, in response to postural stimulation, and in response to a mild behavioral stressor. The short-term stressors led to the expected increases in catecholamines, blood pressure, and heart rate; however, chromogranin A was not influenced by these stimuli. Chromogranin A levels were not higher in the hypertensives, nor were they correlated with any of the other physiological variables. Although chromogranin A is coreleased with catecholamines from the sympathoadrenomedullary system, it does not respond to modest short-term postural or psychological stimuli that simultaneously evoke changes in other variables relevant to the sympathetic nervous system.
对51名未接受药物治疗的志愿者在静息状态下、体位刺激后以及轻度行为应激源刺激后，检测了血浆嗜铬粒蛋白A、去甲肾上腺素、肾上腺素、血压和心率。短期应激源导致儿茶酚胺、血压和心率如预期般升高；然而，嗜铬粒蛋白A不受这些刺激的影响。高血压患者的嗜铬粒蛋白A水平并不更高，也与其他任何生理变量无关。尽管嗜铬粒蛋白A与儿茶酚胺从交感肾上腺髓质系统共同释放，但它对同时引起其他与交感神经系统相关变量变化的适度短期体位或心理刺激无反应。
