Sullivan P A, Grosch C, Lawless D, O'Connor D T
Mallow General Hospital, Mallow, Co. Cork, Ireland.
Ir J Med Sci. 1992 Dec;161(12):666-9. doi: 10.1007/BF02942379.
The effect of a six-week strenuous exercise training programme (modified Bruce protocol, treadmill, three times per week) on resting and exercising blood pressure, heart rate, plasma catecholamines, chromogranin A, renin activity and aldosterone levels was investigated in 15 patients with mild hypertension. An identical exercise test was conducted at baseline and study close (six weeks). At follow-up, seven to ten days after study close, patients completed an exercise test of equivalent intensity to that at baseline, achieving comparable heart rate levels at maximal exercise. On each occasion, blood pressure, heart rate and hormonal variables were measured at rest (supine), maximal exercise and ten minutes after stopping exercise. Resting and exercising blood pressure and heart rate were reduced by the six-week exercise regimen. There was a trend, although not statistically significant, for resting plasma noradrenaline levels to be lower at study close. The reduction in blood pressure and heart rate at maximal exercise was associated with a significant attenuation of the plasma renin response to exercise. Plasma catecholamines also appeared to be lower after exercise training, although this effect was not statistically significant. Plasma levels of chromogranin A and aldosterone measured at rest and maximal exercise were not influenced by the exercise regimen. Further controlled studies are required to corroborate the results of this preliminary study.
在15例轻度高血压患者中，研究了为期六周的剧烈运动训练计划（改良布鲁斯方案，跑步机，每周三次）对静息和运动时血压、心率、血浆儿茶酚胺、嗜铬粒蛋白A、肾素活性及醛固酮水平的影响。在基线和研究结束时（六周）进行了相同的运动测试。在随访时，即研究结束后七至十天，患者完成了与基线强度相当的运动测试，在最大运动时达到了可比的心率水平。每次测量均在静息（仰卧位）、最大运动时及停止运动十分钟后测量血压、心率及激素变量。六周的运动方案降低了静息和运动时的血压及心率。在研究结束时，静息血浆去甲肾上腺素水平有降低趋势，尽管无统计学意义。最大运动时血压和心率的降低与血浆肾素对运动反应的显著减弱相关。运动训练后血浆儿茶酚胺水平似乎也降低了，尽管这一效应无统计学意义。静息和最大运动时测量的血浆嗜铬粒蛋白A和醛固酮水平不受运动方案影响。需要进一步的对照研究来证实这项初步研究的结果。
