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SEOM Clinical Guideline of fertility preservation and reproduction in cancer patients (2016).SEOM癌症患者生育力保存与生殖临床指南(2016年)
Clin Transl Oncol. 2016 Dec;18(12):1229-1236. doi: 10.1007/s12094-016-1587-9. Epub 2016 Nov 28.
2
Fertility preservation in cancer patients: the global framework.癌症患者的生育力保存:全球框架。
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Infertility in reproductive-age female cancer survivors.生殖年龄段女性癌症幸存者的不孕问题。
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Fertility Preservation and Sexual Health After Cancer Therapy.癌症治疗后的生育力保存与性健康
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Fertility preservation and cancer: challenges for adolescent and young adult patients.生育力保存与癌症:青少年及年轻成年患者面临的挑战
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Fertility preservation in cancer survivors.癌症幸存者的生育力保存
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Female fertility preservation in the pediatric and adolescent cancer patient population.儿科和青少年癌症患者的女性生育力保存。
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[Oncofertility: possibilities of preserving reproductive function in cancer patients].[肿瘤生育学:癌症患者保留生殖功能的可能性]
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Association Between Treatment of Childhood Cancer and Its Late Effects on Gonadal or Growth Function in Childhood Cancer Survivors: A Retrospective Observational Study.儿童癌症治疗与其对儿童癌症幸存者性腺或生长功能的晚期影响之间的关联:一项回顾性观察研究。
Cancer Med. 2025 Mar;14(6):e70805. doi: 10.1002/cam4.70805.
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Reproduction in life and death: should cancer patients with a poor prognosis be offered fertility preservation interventions?生死之间的生育问题:预后不良的癌症患者是否应接受生育力保存干预措施?
Reprod Fertil. 2023 Sep 1;4(4). doi: 10.1530/RAF-23-0047.
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Analysis of nuclear maturation, DNA damage and repair gene expression of bovine oocyte and cumulus cells submitted to ionizing radiation.对遭受电离辐射的牛卵母细胞和卵丘细胞的核成熟、DNA损伤及修复基因表达的分析。
Anim Reprod. 2023 May 29;20(2):e20230021. doi: 10.1590/1984-3143-AR2023-0021. eCollection 2023.
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Cancer Treatment-Related Ovarian Dysfunction in Women of Childbearing Potential: Management and Fertility Preservation Options.生育期女性癌症治疗相关卵巢功能障碍:管理和生育力保存选择。
J Clin Oncol. 2023 Apr 20;41(12):2281-2292. doi: 10.1200/JCO.22.01885. Epub 2023 Mar 8.
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The Impact of Malignancy on Assisted Reproductive Outcomes for Cancer Survivors: A Retrospective Case-Control Study.恶性肿瘤对癌症幸存者辅助生殖结局的影响:一项回顾性病例对照研究。
Front Oncol. 2022 Sep 16;12:941797. doi: 10.3389/fonc.2022.941797. eCollection 2022.
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Patients undergoing elective and oncofertility preservation respond similarly to controlled ovarian stimulation for fertility preservation.接受择期和肿瘤生育力保存的患者对控制性卵巢刺激以进行生育力保存的反应相似。
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The Effects of Negative Elements in Environment and Cancer on Female Reproductive System.环境中的负性因素与癌症对女性生殖系统的影响。
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本文引用的文献

1
Fertility preservation in women with cervical, endometrial or ovarian cancers.宫颈癌、子宫内膜癌或卵巢癌女性的生育力保存
Gynecol Oncol Res Pract. 2016 Jul 27;3:8. doi: 10.1186/s40661-016-0029-2. eCollection 2016.
2
Preservation of gonadal function in women undergoing chemotherapy: a review of the potential role for gonadotropin-releasing hormone agonists.化疗女性性腺功能的保护:促性腺激素释放激素激动剂潜在作用的综述
Am J Obstet Gynecol. 2016 Oct;215(4):415-22. doi: 10.1016/j.ajog.2016.06.053. Epub 2016 Jul 13.
3
Obstetric and offspring risks of women's morbid conditions linked to prior anticancer treatments.与既往抗癌治疗相关的女性疾病状态的产科及子代风险。
Reprod Biol Endocrinol. 2016 Jul 7;14(1):37. doi: 10.1186/s12958-016-0169-6.
4
No Evidence for the Benefit of Gonadotropin-Releasing Hormone Agonist in Preserving Ovarian Function and Fertility in Lymphoma Survivors Treated With Chemotherapy: Final Long-Term Report of a Prospective Randomized Trial.没有证据表明促性腺激素释放激素激动剂可改善化疗后淋巴瘤幸存者的卵巢功能和生育能力:一项前瞻性随机试验的最终长期报告。
J Clin Oncol. 2016 Aug 1;34(22):2568-74. doi: 10.1200/JCO.2015.65.8864. Epub 2016 May 23.
5
Fertility Preservation: A Key Survivorship Issue for Young Women with Cancer.生育力保存:年轻癌症女性生存的关键问题。
Front Oncol. 2016 Apr 25;6:102. doi: 10.3389/fonc.2016.00102. eCollection 2016.
6
Fertility preservation in children, adolescents, and young adults with cancer: Quality of clinical practice guidelines and variations in recommendations.癌症患儿、青少年和年轻成人的生育力保存:临床实践指南的质量及推荐意见的差异
Cancer. 2016 Jul 15;122(14):2216-23. doi: 10.1002/cncr.30047. Epub 2016 May 13.
7
Pregnancy after chemotherapy in male and female survivors of childhood cancer treated between 1970 and 1999: a report from the Childhood Cancer Survivor Study cohort.1970年至1999年接受治疗的儿童癌症男女幸存者化疗后的妊娠情况:来自儿童癌症幸存者研究队列的报告
Lancet Oncol. 2016 May;17(5):567-76. doi: 10.1016/S1470-2045(16)00086-3. Epub 2016 Mar 22.
8
Fertility preservation for boys and adolescents facing sterilizing medical therapy.为面临绝育性医学治疗的男孩和青少年保留生育能力。
Transl Androl Urol. 2014 Dec;3(4):382-90. doi: 10.3978/j.issn.2223-4683.2014.11.06.
9
A European perspective on testicular tissue cryopreservation for fertility preservation in prepubertal and adolescent boys.欧洲对青春期前和青春期男孩生育力保存的睾丸组织冷冻保存的观点。
Hum Reprod. 2015 Nov;30(11):2463-75. doi: 10.1093/humrep/dev190. Epub 2015 Sep 10.
10
Ovarian suppression using luteinizing hormone-releasing hormone agonists during chemotherapy to preserve ovarian function and fertility of breast cancer patients: a meta-analysis of randomized studies.化疗中使用促黄体生成素释放激素激动剂抑制卵巢功能以保留乳腺癌患者的卵巢功能和生育能力:一项随机研究的荟萃分析。
Ann Oncol. 2015 Dec;26(12):2408-19. doi: 10.1093/annonc/mdv374. Epub 2015 Sep 7.

SEOM癌症患者生育力保存与生殖临床指南(2016年)

SEOM Clinical Guideline of fertility preservation and reproduction in cancer patients (2016).

作者信息

Muñoz M, Santaballa A, Seguí M A, Beato C, de la Cruz S, Espinosa J, Fonseca P J, Perez J, Quintanar T, Blasco A

机构信息

Servicio de Oncología Médica, Translational Genomics and Targeted Therapeutics in Solid Tumors, IDIBAPS, Hospital Clínic de Barcelona, Villarroel, 170-08036, Barcelona, Spain.

Hospital Universitari I Politècnic la Fe, Valencia, Spain.

出版信息

Clin Transl Oncol. 2016 Dec;18(12):1229-1236. doi: 10.1007/s12094-016-1587-9. Epub 2016 Nov 28.

DOI:10.1007/s12094-016-1587-9
PMID:27896641
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5138251/
Abstract

Chemotherapy and radiotherapy often result in reduced fertility in cancer patients. With increasing survival rates, fertility is an important quality-of-life concern for many young cancer patients. Around 70-75% of young cancer survivors are interested in parenthood but the numbers of patients who access fertility preservation techniques prior to treatment are significantly lower. Moreover, despite existing guidelines, healthcare professionals do not address fertility preservation issues adequately. There is a critical need for improvements in clinical care to ensure patients are well informed about infertility risks and fertility preservation options and to support them in their reproductive decision-making prior to cancer treatment.

摘要

化疗和放疗常常会导致癌症患者生育能力下降。随着生存率的提高,生育能力成为许多年轻癌症患者重要的生活质量关注点。大约70%-75%的年轻癌症幸存者对为人父母感兴趣,但在治疗前采用生育力保存技术的患者数量要低得多。此外,尽管有现有指南,但医疗保健专业人员并未充分解决生育力保存问题。迫切需要改善临床护理,以确保患者充分了解不孕风险和生育力保存选择,并在癌症治疗前支持他们做出生殖决策。