McGoldrick J P, Scott J, Jamieson A, Smyth R, Higenbottam T, Wallwork J
Heart-Lung Transplant Unit, Papworth Hospital, Cambridge, UK.
Transpl Int. 1989 Aug;2(2):68-72. doi: 10.1007/BF02459322.
Fifty-one patients underwent heart-lung transplantation between April 1984 and October 1988. The first five donor organs were removed in an adjacent operating theatre. Organs were subsequently removed from distant centres. The method of preservation consisted of cold cardioplegic arrest of the heart using St. Thomas' solution, followed by a simple, cold pulmonary artery flush of a lung perfusate developed at Papworth Hospital. Administration of the solution was preceded by an infusion of prostacyclin into the pulmonary artery during preliminary dissection of the donor organs. The total ischaemic time ranged from 48 to 51 min (mean 49.6 min) for the near procurement group and from 70 to 249 min (mean 154.2 min) for the distant procurement group. There were no primary organ failures. Function of the lungs was assessed by gas exchange, pulmonary function tests, time to extubation, and survival data. Serial radiological studies were used to monitor graft performance in the postoperative period. We report here on our clinical experience of early graft function following heart and lung transplantation.
1984年4月至1988年10月期间，51例患者接受了心肺移植手术。最初的5个供体器官是在相邻的手术室摘取的。随后的器官则从较远的中心获取。保存方法包括使用圣托马斯液对心脏进行冷停搏，然后用帕普沃思医院研发的一种简单的冷肺灌注液对肺进行肺动脉冲洗。在供体器官初步解剖期间，先向肺动脉内输注前列环素，然后再注入该溶液。近获取组的总缺血时间为48至51分钟（平均49.6分钟），远获取组为70至249分钟（平均154.2分钟）。未出现原发性器官功能衰竭。通过气体交换、肺功能测试、拔管时间和生存数据来评估肺功能。术后通过系列影像学研究监测移植物的性能。我们在此报告心肺移植术后早期移植物功能的临床经验。
