对马拉维淋巴瘤患儿失访导致的生存估计偏差进行量化。
Quantifying bias in survival estimates resulting from loss to follow-up among children with lymphoma in Malawi.
作者信息
Stanley Christopher C, Westmoreland Kate D, Itimu Salama, Salima Ande, van der Gronde Toon, Wasswa Peter, Mtete Idah, Butia Mercy, El-Mallawany Nader K, Gopal Satish
机构信息
UNC Project-Malawi, Lilongwe, Malawi.
University of North Carolina, Chapel Hill, North Carolina.
出版信息
Pediatr Blood Cancer. 2017 Jun;64(6). doi: 10.1002/pbc.26370. Epub 2016 Nov 28.
Abstract
Pediatric lymphoma is common in sub-Saharan Africa, where survival estimates are often based on limited follow-up with incomplete retention, introducing potential for bias. We compared follow-up and overall survival (OS) between passive and active tracing within a prospective cohort of children with lymphoma in Malawi. Median follow-up times were 4.4 months (interquartile range [IQR] 2.0-9.4) and 10.8 months (IQR 6.2-20.6) in passive and active follow-up, respectively. Twelve-month overall survival (OS) was 69% (95% confidence interval [CI] 54-80) in passive and 44% (95% CI 34-54) in active follow-up. Passive follow-up significantly overestimated the OS and underestimated the mortality. Efforts to improve retention in regional studies are needed.
摘要
小儿淋巴瘤在撒哈拉以南非洲地区很常见，该地区的生存估计往往基于随访有限且留存情况不完整的数据，这就存在偏差的可能性。我们在马拉维一个前瞻性淋巴瘤儿童队列中比较了被动追踪和主动追踪的随访情况及总生存率（OS）。被动随访和主动随访的中位随访时间分别为4.4个月（四分位间距[IQR] 2.0 - 9.4）和10.8个月（IQR 6.2 - 20.6）。被动随访的12个月总生存率（OS）为69%（95%置信区间[CI] 54 - 80），主动随访为44%（95% CI 34 - 54）。被动随访显著高估了总生存率并低估了死亡率。需要努力提高区域研究中的留存率。
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