Psychiatry & Psychology Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran. Iran.
Department of Health Sciences Education Development, School of Public Health, Tehran University of Medical Sciences, Tehran. Iran.
Curr Pharm Des. 2017;23(23):3445-3452. doi: 10.2174/1381612822666161129145618.
Some trials on animals and human claim that melatonin can influence body weight. So we conducted a systematic review of controlled trials of melatonin effects on weight of human subjects.
First we performed a systematic and comprehensive search in June 2015 on MEDLINE/PubMed, Scopus, Google scholar, hand searching in key journals, the list of references of selected articles and gray literature.
We included 7 clinical trials with a total of 244 patients. All studies were parallel clinical trials conducted at the clinic. Evaluating standardized mean difference (SMD) using Cohen's method shows that none of the included studies have found a strong and significant effect of melatonin on body weight. However, some have reported decreasing or increasing effect of melatonin on body weight. We pooled SMDs using random effects (DerSimonian and Laird). Pooled SMD was still not significant SMD (95% CI) = 0.09(-0.17-0.34), with lack of heterogeneity I2=0.0%, p=0.66.
We concluded that once the standard treatment had increasing effect on body weight, melatonin could be able to slightly diminish this effect and vice versa. Subgroup analysis showed that melatonin was more effective in child and adolescents. According to the results hypothesis of the buffering role of melatonin on body weight fluctuations can be proposed.
一些动物和人体试验声称褪黑素可以影响体重。因此，我们对褪黑素影响人体体重的对照试验进行了系统综述。
首先，我们于 2015 年 6 月在 MEDLINE/PubMed、Scopus、Google 学术、主要期刊的手工检索、选定文章的参考文献列表和灰色文献中进行了系统和全面的检索。
我们纳入了 7 项临床试验，共 244 例患者。所有研究均为在诊所进行的平行临床试验。使用 Cohen 方法评估标准化均数差（SMD）表明，纳入的研究均未发现褪黑素对体重有强烈而显著的影响。然而，一些研究报告了褪黑素对体重的降低或增加作用。我们使用随机效应（DerSimonian 和 Laird）对 SMD 进行了合并。合并 SMD 仍无显著意义 SMD（95%CI）=0.09（-0.17-0.34），异质性 I2=0.0%，p=0.66。
我们的结论是，一旦标准治疗对体重有增加作用，褪黑素可能能够略微减弱这种作用，反之亦然。亚组分析表明，褪黑素在儿童和青少年中更为有效。根据结果，假设褪黑素对体重波动具有缓冲作用。
