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基于同步辐射 X 射线相衬显微断层成像的肝泡型包虫病可视化及病理学特征

Visualization and Pathological Characteristics of Hepatic Alveolar Echinococcosis with Synchrotron-based X-ray Phase Sensitive Micro-tomography.

机构信息

College of Medical Engineering and Technology, Xinjiang Medical University, Urumchi 830011, China.

Hepatobiliary &Echinococcosis Surgery, FirstAffiliated Hospital, Xinjiang Medical University, Urumchi 830054, China.

出版信息

Sci Rep. 2016 Nov 29;6:38085. doi: 10.1038/srep38085.

DOI:10.1038/srep38085
PMID:27897249
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5126691/
Abstract

Propagation-based phase-contrast computed tomography (PPCT) utilizes highly sensitive phase-contrast technology applied to X-ray micro-tomography, especially with the extensive use of synchrotron radiation (SR). Performing phase retrieval (PR) on the acquired angular projections can enhance image contrast and enable quantitative imaging. We employed the combination of SR-PPCT and PR for the histopathological evaluation of hepatic alveolar echinococcosis (HAE) disease and demonstrated the validity and superiority of PR-based SR-PPCT. A high-resolution angular projection data set of a human postoperative specimen of HAE disease was acquired, which was processed by graded ethanol concentration fixation (GECF). The reconstructed images from both approaches, with the projection data directly used and preprocessed by PR for tomographic reconstruction, were compared in terms of the tissue contrast-to-noise ratio and density spatial resolution. The PR-based SR-PPCT was selected for microscale measurement and the 3D visualization of HAE disease. Our experimental results demonstrated that the PR-based SR-PPCT technique is greatly suitable for the discrimination of pathological tissues and the characterization of HAE. In addition, this new technique is superior to conventional hospital CT and microscopy for the three-dimensional, non-destructive microscale measurement of HAE. This PR-based SR-PPCT technique has great potential for in situmicroscale histopathological analysis and diagnosis, especially for applications involving soft tissues and organs.

摘要

基于相衬的相位对比计算机断层扫描（PPCT）利用高度敏感的相衬技术应用于 X 射线微断层扫描，特别是广泛使用同步辐射（SR）。对采集到的角度投影进行相位恢复（PR）可以增强图像对比度，并实现定量成像。我们将 SR-PPCT 和 PR 相结合，用于肝泡状棘球蚴病（HAE）的组织病理学评估，并证明了基于 PR 的 SR-PPCT 的有效性和优越性。获取了人类 HAE 术后标本的高分辨率角度投影数据集，并用梯度乙醇浓度固定（GECF）进行处理。对直接使用投影数据和 PR 预处理的层析重建的两种方法的重建图像进行了比较，比较了组织对比噪声比和密度空间分辨率。选择基于 PR 的 SR-PPCT 进行 HAE 疾病的微尺度测量和 3D 可视化。我们的实验结果表明，基于 PR 的 SR-PPCT 技术非常适合于病理组织的鉴别和 HAE 的特征化。此外，与传统的医院 CT 和显微镜相比，这种新技术非常适合 HAE 的三维、非破坏性微尺度测量。基于 PR 的 SR-PPCT 技术在原位微尺度组织病理学分析和诊断方面具有很大的潜力，特别是在涉及软组织和器官的应用中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96de/5126691/28915c85682c/srep38085-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96de/5126691/7b86636ce5fe/srep38085-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96de/5126691/4b7dc9e6c971/srep38085-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96de/5126691/9fa3ebc3568a/srep38085-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96de/5126691/df425dd845b1/srep38085-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96de/5126691/891abe123b41/srep38085-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96de/5126691/28915c85682c/srep38085-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96de/5126691/7b86636ce5fe/srep38085-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96de/5126691/4b7dc9e6c971/srep38085-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96de/5126691/9fa3ebc3568a/srep38085-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96de/5126691/df425dd845b1/srep38085-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96de/5126691/891abe123b41/srep38085-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96de/5126691/28915c85682c/srep38085-f6.jpg

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Boundary-enhancement in propagation-based x-ray phase-contrast tomosynthesis improves depth position characterization.
体外鉴定血管生成拟态的结构和功能。
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