Lipina Christopher, Hundal Harinder S
Division of Cell Signalling and Immunology, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.
J Cachexia Sarcopenia Muscle. 2017 Apr;8(2):190-201. doi: 10.1002/jcsm.12144. Epub 2016 Oct 8.
Loss of skeletal muscle mass is a characteristic feature of various pathologies including cancer, diabetes, and obesity, as well as being a general feature of ageing. However, the processes underlying its pathogenesis are not fully understood and may involve multiple factors. Importantly, there is growing evidence which supports a role for fatty acids and their derived lipid intermediates in the regulation of skeletal muscle mass and function. In this review, we discuss evidence pertaining to those pathways which are involved in the reduction, increase and/or preservation of skeletal muscle mass by such lipids under various pathological conditions, and highlight studies investigating how these processes may be influenced by dietary supplementation as well as genetic and/or pharmacological intervention.
骨骼肌质量的丧失是包括癌症、糖尿病和肥胖症在内的各种病理状况的一个特征，也是衰老的一个普遍特征。然而，其发病机制背后的过程尚未完全了解，可能涉及多种因素。重要的是，越来越多的证据支持脂肪酸及其衍生的脂质中间体在调节骨骼肌质量和功能方面发挥作用。在这篇综述中，我们讨论了在各种病理条件下，这些脂质参与骨骼肌质量减少、增加和/或维持的相关途径的证据，并重点介绍了研究这些过程如何受到膳食补充以及基因和/或药物干预影响的研究。
