McAreavey D, Neilson J M, Ewing D J, Russell D C
Cardiovascular Research Unit, University of Edinburgh.
Br Heart J. 1989 Sep;62(3):165-70. doi: 10.1136/hrt.62.3.165.
Cardiac parasympathetic activity was assessed in 21 patients during the first 24 hours of acute myocardial infarction by measuring abrupt beat by beat changes in RR interval, which are expressed as "RR counts". Eleven patients had inferior wall infarction and 10 had anterior wall myocardial infarction. The whole recording period was analysed in 11 patients (five inferior and six anterior), and intermittent hourly periods were analysed in all 21 subjects. Mean RR counts were significantly lower in patients with anterior than inferior infarction, and below the normal range. Although mean heart rates were faster in the group with anterior infarction, there was a dissociation between RR counts and mean heart rate that was consistent with RR interval variability being an independent measure of parasympathetic activity. This study indicates that cardiac parasympathetic activity during acute myocardial infarction can be simply and reliably assessed from continuous electrocardiographic recordings, and it showed significantly lower cardiac parasympathetic activity in patients with anterior infarction.
通过测量RR间期逐搏的突然变化（以“RR计数”表示），对21例急性心肌梗死患者在发病后24小时内的心脏副交感神经活动进行了评估。11例患者为下壁梗死，10例为前壁心肌梗死。对11例患者（5例下壁梗死和6例前壁梗死）的整个记录期进行了分析，对所有21例受试者的每小时间歇性时段进行了分析。前壁梗死患者的平均RR计数显著低于下壁梗死患者，且低于正常范围。尽管前壁梗死组的平均心率较快，但RR计数与平均心率之间存在分离，这与RR间期变异性是副交感神经活动的独立指标一致。本研究表明，急性心肌梗死期间的心脏副交感神经活动可通过连续心电图记录进行简单可靠的评估，且显示前壁梗死患者的心脏副交感神经活动显著降低。
