卵圆孔未闭的超声心动图随访及影响自然闭合的因素

Echocardiographic Follow-Up of Patent Foramen Ovale and the Factors Affecting Spontaneous Closure.

作者信息

Yildirim Ali, Aydin Alperen, Demir Tevfik, Aydin Fatma, Ucar Birsen, Kilic Zubeyir

机构信息

Department of Pediatric.

Department of Pediatric Cardiology, Medical Faculty, Eskisehir Osmangazi University, Eskisehir, Turkey.

出版信息

Acta Cardiol Sin. 2016 Nov;32(6):731-737. doi: 10.6515/acs20160205a.

DOI:10.6515/acs20160205a

PMID:27899861

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5126452/

Abstract

BACKGROUND

The aim of the present study was to evaluate the echocardiographic follow-up of patent foramen ovale, which is considered a potential etiological factor in various diseases, and to determine the factors affecting spontaneous closure.

METHODS

Between January 2000 and June 2012, records of 918 patients with patent foramen ovale were retrospectively reviewed. Patency of less than 3 mm around the fossa ovalis is called patent foramen ovale. Patients with cyanotic congenital heart diseases, severe heart valve disorders and severe hemodynamic left to right shunts were excluded from the study. The patients were divided into three groups based on age; 1 day-1 month in group 1, 1 month-12 months in group 2, and more than 12 months in group 3.

RESULTS

Of the 918 patients, 564 (61.4%) had spontaneous closure, 328 (35.8%) had patent foramen ovale continued, 15 (1.6%) patients had patent foramen ovale enlarged to 3-5 mm, 6 patients were enlarged to 5-8 mm, and in one patient patent foramen ovale reached to more than 8 mm size. Defect was spontaneously closed in 65.9% of the patients in group 1, 66.7% of the patients in group 2, and 52.3% of the patients in group 3. There was a negative correlation between the age of diagnosis and spontaneous closure (p < 0.05). Gender, prematurity and coexisting malformations such as patent ductus arteriosus and atrial septal aneurysm did not have any effect on spontaneous closure of patent foramen ovale (p > 0.05). However, ventricular septal defect and spontaneous closure of patent foramen ovale had a positive correlation (p < 0.01). No correlation was noted between the existence of atrial septal aneurysm, prematurity, and maturity of the patients.

CONCLUSIONS

The present study demonstrated that spontaneous closure rate of patent foramen ovale is high. Furthermore, a positive correlation was found between spontaneous closure of patent foramen ovale with early diagnosis and small defect size.

摘要

背景

本研究旨在评估卵圆孔未闭的超声心动图随访情况，卵圆孔未闭被认为是多种疾病的潜在病因，并确定影响自然闭合的因素。

方法

回顾性分析2000年1月至2012年6月期间918例卵圆孔未闭患者的记录。卵圆窝周围小于3mm的未闭称为卵圆孔未闭。患有青紫型先天性心脏病、严重心脏瓣膜疾病和严重血流动力学左向右分流的患者被排除在研究之外。根据年龄将患者分为三组；第1组为1天至1个月，第2组为1个月至12个月，第3组为超过12个月。

结果

918例患者中，564例（61.4%）自然闭合，328例（35.8%）卵圆孔未闭持续存在，15例（1.6%）患者卵圆孔未闭扩大至3 - 5mm，6例扩大至5 - 8mm，1例患者卵圆孔未闭直径超过8mm。第1组65.9%的患者缺损自然闭合，第2组66.7%的患者缺损自然闭合，第3组52.3%的患者缺损自然闭合。诊断年龄与自然闭合之间存在负相关（p < 0.05）。性别、早产以及动脉导管未闭和房间隔瘤等并存畸形对卵圆孔未闭的自然闭合没有任何影响（p > 0.05）。然而，室间隔缺损与卵圆孔未闭的自然闭合呈正相关（p < 0.01）。未发现房间隔瘤的存在、早产与患者成熟度之间存在相关性。