Görne Rainer C, Wegener Tankred, Kelber Olaf, Feistel Björn, Reichling Jürgen
Working group "Efficacy and Safety" of the Kooperation Phytopharmaka GbR, Plittersdorfer Str. 218, 53173, Bonn-Bad Godesberg, Germany.
Praxis für Diabetologie und Naturwissenschaftliche Medizin, Karl-Helfferich-Str. 9A, 67433, Neustadt an der Weinstraße, Germany.
Wien Med Wochenschr. 2017 May;167(7-8):177-182. doi: 10.1007/s10354-016-0526-2. Epub 2016 Nov 29.
In this review, results of randomized double-blind controlled clinical trials (RCTs) with extracts of Serenoa repens fruits at a dose of 320 mg/d for the treatment of lower urinary tract symptoms (LUTS) are assessed. Of the RTCs conducted for up to 6 months, a benefit was seen in three of three RTCs with ethanolic, in eight of nine RTCs with hexane, and in one of two RTCs with CO extracts. Of the RTCs conducted for more than 6 months, a benefit was seen in two RTCs with hexane and in one RTC with CO extracts, whereas one RTC with an ethanolic, two RTCs with hexane, and one RTC with CO extracts did not show positive results. As LUTS are dynamic conditions with strong spontaneous fluctuation over time, the majority of patients might expect improvement of single symptoms and thus of quality of life, particularly as the extracts are well tolerated even in long-term treatment.
在本综述中，评估了使用剂量为320毫克/天的锯叶棕果实提取物治疗下尿路症状（LUTS）的随机双盲对照临床试验（RCT）结果。在长达6个月的RCT中，使用乙醇提取物的3项RCT中有3项显示出益处，使用己烷提取物的9项RCT中有8项显示出益处，使用CO提取物的2项RCT中有1项显示出益处。在超过6个月的RCT中，使用己烷提取物的2项RCT和使用CO提取物的1项RCT显示出益处，而使用乙醇提取物的1项RCT、使用己烷提取物的2项RCT和使用CO提取物的1项RCT未显示出阳性结果。由于LUTS是一种随时间有强烈自发波动的动态病症，大多数患者可能期望单一症状得到改善，从而改善生活质量，特别是因为即使在长期治疗中，提取物的耐受性也良好。
