Ko Nai-Ying
PhD, RN, Professor, Department of Nursing, College of Medicine, National Cheng Kung University, and Associate Director, Department of Nursing, National Cheng Kung University Hospital, Taiwan, ROC.
Hu Li Za Zhi. 2016 Dec;63(6):18-22. doi: 10.6224/JN.63.6.18.
Pre-exposure prophylaxis (PrEP), in combination with traditional prevention strategies (such as condom use, voluntary HIV counseling and testing, and treatment for sexually transmitted infections), has been shown to effectively prevent HIV infection. As of September 2015, the World Health Organization recommends that people at substantial risk of HIV infection should be offered PrEP as an additional prevention choice, as part of comprehensive prevention. This article introduces how to apply a systematic review using the methodology of Grading of Recommendations Assessment, Development and Evaluation (GRADE) to write clinical guidelines. With support from the Taiwan Centers for Disease Control, the Taiwan AIDS Society published clinical guidelines for oral pre-exposure prophylaxis in Taiwan. Nurses are responsible to apply evidence-based knowledge and to use their professional influence to shape health policies related to HIV prevention.
暴露前预防（PrEP）与传统预防策略（如使用避孕套、自愿接受HIV咨询和检测以及性传播感染治疗）相结合，已被证明能有效预防HIV感染。截至2015年9月，世界卫生组织建议，作为综合预防的一部分，应向有高HIV感染风险的人群提供PrEP作为额外的预防选择。本文介绍如何运用推荐分级的评估、制定和评价（GRADE）方法进行系统评价以撰写临床指南。在台湾疾病控制中心的支持下，台湾艾滋病协会发布了台湾口服暴露前预防的临床指南。护士有责任应用循证知识，并利用其专业影响力来制定与HIV预防相关的卫生政策。
