Tiurin V A, Korol'kov S N, Kagan V E
Biokhimiia. 1989 Jun;54(6):940-7.
The alpha-tocopherol content and fatty acid composition of lipids in various types of nervous tissue membranes were studied. The transbilayer distribution of alpha-tocopherol and polyunsaturated fatty acids in liposomes and plasma membranes of synaptosomes was examined. It was shown that both phosphatidylethanolamine and phosphatidylserine are localized predominantly in the inner monolayer and they contain the bulk of polyenoic fatty acid residues. alpha-Tocopherol incorporated into liposomes from synaptosome plasma membrane lipids and present in synaptosome plasma membranes is also predominantly localized in the inner monolayers. No asymmetrical distribution of incorporated alpha-tocopherol was observed in liposomes prepared from a single phospholipid, e.g., dioleoylphosphatidylcholine.
研究了各种类型神经组织膜中脂质的α-生育酚含量和脂肪酸组成。检测了α-生育酚和多不饱和脂肪酸在突触体脂质体和质膜中的跨膜分布。结果表明，磷脂酰乙醇胺和磷脂酰丝氨酸主要定位于内膜层，且它们含有大部分多烯脂肪酸残基。从突触体质膜脂质掺入脂质体并存在于突触体质膜中的α-生育酚也主要定位于内膜层。在由单一磷脂（如二油酰磷脂酰胆碱）制备的脂质体中未观察到掺入的α-生育酚的不对称分布。
