抑郁症、性功能与纤维肌痛综合征：临床发现及其与血液学参数的相关性。
Depression, sexuality and fibromyalgia syndrome: clinical findings and correlation to hematological parameters.
作者信息
Alves Bruna, Zakka Telma M, Teixeira Manoel J, Kaziyama Helena H, Siqueira Jose T T, Siqueira Silvia R D T
机构信息
Universidade de São Paulo, Escola de Artes, Ciências e Humanidades, São Paulo SP, Brasil.
Universidade de São Paulo, Faculdade de Medicina, Centro Interdisciplinar de Dor, Departamento de Neurologia, São Paulo SP, Brasil.
出版信息
Arq Neuropsiquiatr. 2016 Nov;74(11):863-868. doi: 10.1590/0004-282X20160141.
OBJECTIVE
To investigate sexuality and depression in women with FM compared with controls and to correlate the findings with hematological parameters.
METHODS
33 women with FM and 19 healthy women were included and evaluated with the following instruments: Female Sexual Function Index, Beck Inventory, Visual Analogue Scale, medical history and laboratory exams.
RESULTS
The prevalence of sexual dysfunction (P = 0.007) and depression (P < 0.001) were higher in the study group than in the control group; they were positively correlated (P = 0.023). The study group showed lower serum concentrations of testosterone, free T4, antinuclear factor, and lower blood hemoglobin and hematocrit.
CONCLUSIONS
FM was associated with high scores of sexual dysfunction and depression, and there were correlations with hematological parameters. We suggest the involvement of immune-inflammatory mediators and FM, which need further investigation to understand their role in FM syndrome and its comorbidities.
目的
与对照组相比，调查纤维肌痛（FM）女性的性功能和抑郁情况，并将研究结果与血液学参数相关联。
方法
纳入33名FM女性和19名健康女性，并用以下工具进行评估：女性性功能指数、贝克量表、视觉模拟量表、病史和实验室检查。
结果
研究组性功能障碍（P = 0.007）和抑郁（P < 0.001）的患病率高于对照组；二者呈正相关（P = 0.023）。研究组血清睾酮、游离T4、抗核因子浓度较低，血红蛋白和血细胞比容也较低。
结论
FM与性功能障碍和抑郁的高分相关，且与血液学参数存在关联。我们认为免疫炎症介质与FM有关，这需要进一步研究以了解它们在FM综合征及其合并症中的作用。
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