Schier Mara F, Raisis Anthea L, Secombe Cristy J, Hosgood Giselle, Musk Gabrielle C, Lester Guy D
Am J Vet Res. 2016 Dec;77(12):1318-1324. doi: 10.2460/ajvr.77.12.1318.
OBJECTIVE To determine the effects of acepromazine maleate premedication on cardiovascular function before and after infusion of dobutamine hydrochloride for 30 minutes in isoflurane-anesthetized horses. ANIMALS 6 healthy adult horses. PROCEDURES Each horse was anesthetized once following premedication with acepromazine (0.02 mg/kg, IV) administered 30 minutes prior to anesthetic induction (ACP+ treatment) and once without premedication (ACP- treatment). Anesthesia was induced with IV administration of xylazine hydrochloride (0.8 mg/kg), ketamine hydrochloride (2.2 mg/kg), and diazepam (0.08 mg/kg). Horses were positioned in right lateral recumbency, and anesthesia was maintained via inhalation of isoflurane delivered in oxygen. End-tidal isoflurane concentration was adjusted to achieve a target mean arterial blood pressure of 60 mm Hg (interquartile range [25th to 75th percentile], 57 to 63 mm Hg) for at least 15 minutes. Cardiac index, oxygen delivery index, and femoral arterial blood flow indices were determined 60 minutes after anesthetic induction (baseline). Dobutamine was then infused to achieve a target mean arterial blood pressure of 80 mm Hg (interquartile range, 76 to 80 mm Hg). Data collection was repeated 30 minutes after the start of dobutamine infusion for comparison with baseline values. RESULTS Complete data sets were available from 5 of the 6 horses. Dobutamine administration resulted in significant increases in oxygen delivery and femoral arterial blood flow indices but no significant change in cardiac index for each treatment. However, at baseline or 30 minutes after the start of dobutamine infusion, findings for the ACP+ and ACP- treatments did not differ. CONCLUSIONS AND CLINICAL RELEVANCE In isoflurane-anesthetized horses, dobutamine administration increased oxygen delivery and femoral arterial blood flow indices, but these changes were unaffected by premedication with acepromazine.
目的 确定在异氟烷麻醉的马匹中，盐酸阿扑吗啡预处理对静脉输注盐酸多巴酚丁胺30分钟前后心血管功能的影响。动物 6匹健康成年马。方法 每匹马在麻醉诱导前30分钟静脉注射阿扑吗啡（0.02 mg/kg）进行预处理后麻醉一次（ACP+处理），且在未进行预处理的情况下麻醉一次（ACP-处理）。通过静脉注射盐酸赛拉嗪（0.8 mg/kg）、盐酸氯胺酮（2.2 mg/kg）和地西泮（0.08 mg/kg）诱导麻醉。马匹取右侧卧位，通过吸入氧气中的异氟烷维持麻醉。将呼气末异氟烷浓度调整至目标平均动脉血压为60 mmHg（四分位间距[第25至75百分位数]，57至63 mmHg）至少15分钟。在麻醉诱导60分钟后（基线）测定心脏指数、氧输送指数和股动脉血流指数。然后输注多巴酚丁胺以达到目标平均动脉血压80 mmHg（四分位间距，76至80 mmHg）。在多巴酚丁胺输注开始30分钟后重复数据收集，以便与基线值进行比较。结果 6匹马中有5匹获得了完整的数据集。对于每种处理，多巴酚丁胺给药导致氧输送和股动脉血流指数显著增加，但心脏指数无显著变化。然而，在基线或多巴酚丁胺输注开始30分钟后，ACP+和ACP-处理的结果并无差异。结论及临床意义 在异氟烷麻醉的马匹中，多巴酚丁胺给药增加了氧输送和股动脉血流指数，但这些变化不受阿扑吗啡预处理的影响。
