特应性角结膜炎炎症的血管造影评估。
Angiographic Evaluation of Inflammation in Atopic Keratoconjunctivitis.
机构信息
a Department of Ophthalmology , Medical University of Innsbruck , Innsbruck , Austria.
b Department of Corneal and External Eye Diseases , St. Paul's Eye Unit, Royal Liverpool University Hospital , Liverpool , United Kingdom.
出版信息
Ocul Immunol Inflamm. 2018;26(5):685-688. doi: 10.1080/09273948.2016.1247873. Epub 2016 Nov 30.
PURPOSE
Grading of disease activity in patients with atopic keratoconjunctivitis (AKC) is limited by intra- and inter-observer variability. The aim of this study was to identify angiographic parameters to help evaluate inflammation and disease activity.
METHODS
In 12 patients (4 with active, 2 with inactive AKC, and 6 controls), disease activity were assessed using a validated biomicroscopic grading scale. Imaging of upper tarsal conjunctiva was undertaken using color photography, fluorescein (FA) and indocyanine green angiography (ICGA).
RESULTS
Extravascular ICG leakage only occurred in patients with active disease (mean 84.6 ± 28.8 s) except in one patient with inactive disease but only after 6 min. Transepithelial leakage of fluorescein occurred in all patients with active AKC (mean 63.5 ± 17.8 s) but not in patients with inactive disease or controls.
CONCLUSIONS
Conjunctival transepithelial leakage of fluorescein and extravascular interstitial accumulation of ICG may be useful markers of disease activity patients in AKC.
目的
特应性角结膜炎（AKC）患者的疾病活动度分级受到观察者内和观察者间变异性的限制。本研究旨在确定血管造影参数，以帮助评估炎症和疾病活动度。
方法
在 12 名患者（4 名活动期 AKC、2 名非活动期 AKC 和 6 名对照组）中，使用经过验证的生物显微镜分级量表评估疾病活动度。采用彩色摄影、荧光素（FA）和吲哚菁绿血管造影（ICGA）对上睑结膜进行成像。
结果
血管外 ICG 渗漏仅发生在活动期疾病患者中（平均 84.6 ± 28.8 s），除了一名非活动期疾病患者，但仅在 6 分钟后。所有活动期 AKC 患者均出现荧光素经上皮渗漏（平均 63.5 ± 17.8 s），而非活动期疾病患者或对照组则无此现象。
结论
荧光素经上皮渗漏和 ICG 血管外间质积聚可能是 AKC 患者疾病活动度的有用标志物。
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