基于急性肾损伤网络的重症监护病房急性肾损伤结局
Outcome of Acute Kidney Injury in Critical Care Unit, Based on AKI Network.
作者信息
Hashemian Seyed Mohammadreza, Jamaati Hamidreza, Farzanegan Bidgoli Behrooz, Farrokhi Farin Rashid, Malekmohammad Majid, Roozdar Sepehr, Mohajerani Seyed Amir, Bagheri Ahmad, Radmnand Golnar, Hatami Behzad, Chitsazan Mandana
机构信息
Chronic Respiratory Disease Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Tobacco Prevention and Control Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Tanaffos. 2016;15(2):89-95.
BACKGROUND
Acute Kidney Injury (AKI) is an unsolved clinical problem in critical care patients with a high mortality rate, increasing incidence, and no definitive therapy. We studied the incidence, risk factors, and mortality associated with AKI in ICU patients.
MATERIALS AND METHODS
In a prospective study, patient demographics, reason for hospitalization, reason for ICU admission, Length of ICU stay, laboratory data, and Vital signs were recorded in prepared forms during the ICU stay. AKI was defined as an increase in serum creatinine (SCr) of ≥ 0.3mg/dl from the baseline.
RESULTS
A total of 200 patients who were enrolled in our study; 134 (67%) did not develop AKI during their ICU stay while 66 (33%) developed AKI (SCr ≥ 0.3) according to the AKIN definition. Patients with AKI had higher APACHE II scores (12.3±5.6 vs. 6.9±3.6; P< 0.001), longer ICU stays (7.6±7.6 vs. 3.7±2.8 days respectively; P< 0.001), and higher mortality (19.7% vs. 0.7%; P< 0.001).
CONCLUSION
The AKIN criteria are clinically valid and can be a good predictor of mortality and patient outcome in addition to APACHE II score in ICU patients.
背景
急性肾损伤（AKI）是重症监护患者中一个尚未解决的临床问题，死亡率高、发病率上升且尚无确切治疗方法。我们研究了重症监护病房（ICU）患者中与AKI相关的发病率、危险因素和死亡率。
材料与方法
在一项前瞻性研究中，在ICU住院期间，以预先准备好的表格记录患者的人口统计学资料、住院原因、入住ICU的原因、ICU住院时间、实验室数据和生命体征。AKI定义为血清肌酐（SCr）较基线水平升高≥0.3mg/dl。
结果
共有200名患者纳入我们的研究；根据AKIN定义，134名（67%）患者在ICU住院期间未发生AKI，而66名（33%）患者发生了AKI（SCr≥0.3）。发生AKI的患者APACHE II评分更高（分别为12.3±5.6 vs. 6.9±3.6；P<0.001），ICU住院时间更长（分别为7.6±7.6天 vs. 3.7±2.8天；P<0.001），死亡率更高（19.7% vs. 0.7%；P<0.001）。
结论
AKIN标准在临床上是有效的，除了APACHE II评分外，还可以很好地预测ICU患者的死亡率和预后。
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