Vosoughi Nooshin, Kashefi Parviz, Abbasi Behnood, Feizi Awat, Askari Gholamreza, Azadbakht Leila
Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Anesthesiology and Critical Care, Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Med Sci. 2016 Sep 1;21:75. doi: 10.4103/1735-1995.189692. eCollection 2016.
According to the high prevalence of Vitamin D deficiency, a few studies have been conducted to clarify the relationship between 25-hydroxyvitamin D (25(OH)D) and clinical outcomes in critically ill patients. The objective of this study was to determine this probable association.
Serum 25(OH)D, C-reactive protein, malnutrition measurements, and Intensive Care Unit (ICU)-acquired infection from 185 patients in ICU were assessed in the first 24 h of admission and they were followed for the other outcomes.
About 93.5% of patients were classified as deficient and insufficient while the others were categorized in sufficient group. 25(OH)D status was not significantly associated with mortality rate ( = 0.66), and no significant differences in ventilation time were observed ( = 0.97). Sufficient group left the ICU sooner, but the difference was not significant ( = 0.75). Besides the results of relationship between 25(OH)D concentration and nutritional status ( = 0.69) were not significant. In addition, sufficient group suffered from infection more than insufficient patients, but this relationship was not significant ( = 0.11).
In this study, we found that 25(OH)D insufficiency is common in ICU patients, but no significant association between low 25(OH)D levels and ICU outcomes were observed. Hence, because of vital roles of Vitamin D in human's body, comprehensive study should conduct to determine the decisive results.
鉴于维生素D缺乏的高患病率，已经开展了一些研究以阐明25-羟基维生素D（25(OH)D）与危重症患者临床结局之间的关系。本研究的目的是确定这种可能的关联。
对185例入住重症监护病房（ICU）的患者在入院后的最初24小时内评估其血清25(OH)D、C反应蛋白、营养状况测量指标以及ICU获得性感染情况，并对其他结局进行随访。
约93.5%的患者被归类为维生素D缺乏和不足，其余患者被归类为充足组。25(OH)D状态与死亡率无显著相关性（P = 0.66），通气时间也无显著差异（P = 0.97）。充足组离开ICU的时间更早，但差异不显著（P = 0.75）。此外，25(OH)D浓度与营养状况之间的关系结果也不显著（P = 0.69）。另外，充足组比不足组感染发生率更高，但这种关系不显著（P = 0.11）。
在本研究中，我们发现ICU患者中25(OH)D不足很常见，但未观察到低25(OH)D水平与ICU结局之间存在显著关联。因此，鉴于维生素D在人体中的重要作用，应开展全面研究以确定确切结果。
