Ichikawa M
Department of Anatomy and Embryology, Tokyo Metropolitan Institute for Neurosciences, Japan.
Brain Res. 1989 Sep 25;498(1):45-52. doi: 10.1016/0006-8993(89)90397-1.
It has been shown that male rats demonstrate a preference for the odor of the female rat. This preference has been suggested to be a function of the accessory olfactory pathway. Thus, changes in preference of the male rat for the odor of the female were examined following accessory olfactory bulb (AOB) removal. Preference decreased to about 30% of that seen in the intact rat during the 10 days following AOB removal. Thereafter, it increased gradually over one month survival time up to approximately 70% of the level demonstrated by the intact rat. The rats whose main olfactory bulb and AOB were removed did not show any recovery at any survival time. The time course of the behavioral recovery after AOB removal was compared with the time course of the recovery of synaptic density which was observed in the medial amygdaloid nucleus after AOB removal. The relationship between functional recovery and reorganization of synaptic connections is discussed.
研究表明，雄性大鼠对雌性大鼠的气味表现出偏好。这种偏好被认为是副嗅通路的一种功能。因此，在摘除副嗅球（AOB）后，研究了雄性大鼠对雌性气味偏好的变化。在摘除AOB后的10天内，偏好降至完整大鼠的约30%。此后，在长达一个月的存活期内逐渐增加，直至达到完整大鼠所表现水平的约70%。主嗅球和AOB均被摘除的大鼠在任何存活时间都未表现出任何恢复。将摘除AOB后行为恢复的时间进程与摘除AOB后在内侧杏仁核中观察到的突触密度恢复的时间进程进行了比较。并讨论了功能恢复与突触连接重组之间的关系。
