Szymusiak R, McGinty D
Department of Psychology, University of California, Los Angeles.
Brain Res. 1989 Oct 2;498(2):355-9. doi: 10.1016/0006-8993(89)91116-5.
Neurons in the lateral basal forebrain which discharge selectively during slow-wave sleep have been identified as projecting to the midbrain reticular formation. Such cells have been hypothesized to participate in sleep-related changes in reticular formation excitability. The effects of stimulation at these sites on reticular formation single unit discharge in behaving cats was quantified in the present study. Effects were compared to those evoked from medial basal forebrain sites, including the preoptic area/anterior hypothalamus. Stimulation at all of these basal forebrain sites typically produced biphasic responses, consisting of a brief, short-latency excitation, followed by discharge suppression. Stimulation at lateral sites resulted in significantly longer periods of discharge suppression compared to stimulation at medial sites. These results support the hypothesis that laterally situated basal forebrain neurons participate in the regulation of behavioral state, in part, via descending modulation of midbrain reticular formation arousal mechanisms.
已确定在慢波睡眠期间选择性放电的外侧基底前脑神经元投射到中脑网状结构。据推测，这类细胞参与了与睡眠相关的网状结构兴奋性变化。在本研究中，对这些部位的刺激对行为猫网状结构单个单位放电的影响进行了量化。将这些影响与内侧基底前脑部位（包括视前区/下丘脑前部）所诱发的影响进行了比较。所有这些基底前脑部位的刺激通常产生双相反应，包括短暂的、潜伏期短的兴奋，随后是放电抑制。与内侧部位的刺激相比，外侧部位的刺激导致放电抑制的时间明显更长。这些结果支持这样的假说，即位于外侧的基底前脑神经元部分地通过对中脑网状结构唤醒机制的下行调节参与行为状态的调节。
