Benke Kálmán, Sayour Alex Ali, Mátyás Csaba, Ágg Bence, Németh Balázs Tamás, Oláh Attila, Ruppert Mihály, Hartyánszky István, Szabolcs Zoltán, Radovits Tamás, Merkely Béla, Szabó Gábor
1 Heart and Vascular Center, Semmelweis University, Budapest, Hungary. 2 Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany.
Transplantation. 2017 Mar;101(3):498-505. doi: 10.1097/TP.0000000000001585.
Heterotopic abdominal rat heart transplantation has been extensively used to investigate ischemic-reperfusion injury, immunological consequences during heart transplantations and also to study remodeling of the myocardium due to volume unloading. We provide a unique review on the latter and present a summary of the experimental studies on rat heart transplantation to illustrate changes that occur to the myocardium due to volume unloading. We divided the literature based on whether normal or failing rat heart models were used. This analysis may provide a basis to understand the physiological effects of mechanical circulatory support therapy.
异位腹部大鼠心脏移植已被广泛用于研究缺血再灌注损伤、心脏移植过程中的免疫后果，以及研究因容量卸载导致的心肌重塑。我们对后者进行了独特的综述，并总结了大鼠心脏移植的实验研究，以说明因容量卸载而在心肌中发生的变化。我们根据是否使用正常或衰竭大鼠心脏模型对文献进行了分类。该分析可为理解机械循环支持治疗的生理效应提供依据。
