表现为骨髓纤维化的霍奇金淋巴瘤。

Hodgkin's disease presenting as myelofibrosis.

作者信息

Meadows L M, Rosse W R, Moore J O, Crawford J, Laszlo J, Kaufman R E

机构信息

Department of Medicine, University of North Carolina at Chapel Hill 27599.

出版信息

Cancer. 1989 Oct 15;64(8):1720-6. doi: 10.1002/1097-0142(19891015)64:8<1720::aid-cncr2820640828>3.0.co;2-l.

DOI:10.1002/1097-0142(19891015)64:8<1720::aid-cncr2820640828>3.0.co;2-l

PMID:2790685

Abstract

Four patients with Hodgkin's disease and bone marrow fibrosis are presented in whom the clinical presentation was dominated by cytopenias; this was associated with a delayed diagnosis for an average of 20 months. Despite marrow involvement, chemotherapy resulted in complete remissions and two patients appear to have been cured. Marrow fibrosis resolved at least partially after chemotherapy. The medical literature relevant to bone marrow involvement by Hodgkin's disease is reviewed. Hodgkin's disease should be considered in the differential diagnosis of idiopathic myelofibrosis.

摘要

本文报告了4例霍奇金病合并骨髓纤维化患者，其临床表现以血细胞减少为主，平均延迟诊断20个月。尽管骨髓受累，但化疗导致完全缓解，2例患者似乎已治愈。化疗后骨髓纤维化至少部分缓解。本文回顾了与霍奇金病骨髓受累相关的医学文献。在特发性骨髓纤维化的鉴别诊断中应考虑霍奇金病。