Sawyer J, Tuchman M
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock.
Cancer Genet Cytogenet. 1989 Oct 1;42(1):99-106. doi: 10.1016/0165-4608(89)90012-5.
Cytogenetic analysis of two murine neuroblastoma cell lines that show different malignant expression revealed consistent differences in the chromosomal composition between the two lines. The MNB-T1 (high-malignancy) cell line showed increased modal chromosome number, presence of homogeneously staining regions (HSRs), double minutes (dmin) and evidence of secondary chromosomal events when compared with the MNB-T2 (low-malignancy) cell line, which did not express these cytogenetic characteristics. Several of the cytogenetic events that have occurred in these murine cell lines, such as HSRs, dmin, and chromosomal deletions, have also been reported in human neuroblastoma cell lines. When comparisons are made for the involvement of chromosomal regions known to be involved in human neuroblastoma, similar tumor specific regions seem to be involved in the homologous mouse chromosomes.
对两个表现出不同恶性表达的小鼠神经母细胞瘤细胞系进行细胞遗传学分析，结果显示这两个细胞系在染色体组成上存在一致的差异。与不表达这些细胞遗传学特征的MNB-T2（低恶性）细胞系相比，MNB-T1（高恶性）细胞系显示出模式染色体数增加、存在均匀染色区（HSR）、双微体（dmin）以及继发性染色体事件的证据。这些小鼠细胞系中发生的一些细胞遗传学事件，如HSR、dmin和染色体缺失，在人类神经母细胞瘤细胞系中也有报道。当对已知参与人类神经母细胞瘤的染色体区域的参与情况进行比较时，类似的肿瘤特异性区域似乎也参与了同源小鼠染色体。
