Sessarego M, Mareni C, Vimercati R, Defferrari R, Origone P, Damasio E, Ajmar F
Cattedra di Clinica Medica R, Università di Genova, Italy.
Cancer Genet Cytogenet. 1989 Nov;43(1):51-6. doi: 10.1016/0165-4608(89)90126-x.
Chromosome analysis showed a t(9;9)(p13;q34) in a patient with chronic myeloid leukemia (CML) without a Philadelphia (Ph) chromosome in all examined cells. Southern blot analysis of leukocyte DNA revealed rearrangement of breakpoint cluster region (bcr) within the 5.8-kb bcr sequences as in Ph-positive CML patients. The findings confirm that the 9q34 and 22q11 bands are always involved in CML independent of the chromosomal evidence. It is suggested that Ph-negative bcr-positive CML may have variant translocations, as in the case of the t(9;9) reported here.
