In simulations of electrical-acoustic stimulation (EAS), vocoded speech intelligibility is aided by preservation of low-frequency acoustic cues. However, the speech signal is often interrupted in everyday listening conditions, and effects of interruption on hybrid speech intelligibility are poorly understood. Additionally, listeners rely on information-bearing acoustic changes to understand full-spectrum speech (as measured by cochlea-scaled entropy [CSE]) and vocoded speech (CSE), but how listeners utilize these informational changes to understand EAS speech is unclear. Here, normal-hearing participants heard noise-vocoded sentences with three to six spectral channels in two conditions: vocoder-only (80-8000 Hz) and simulated hybrid EAS (vocoded above 500 Hz; original acoustic signal below 500 Hz). In each sentence, four 80-ms intervals containing high-CSE or low-CSE acoustic changes were replaced with speech-shaped noise. As expected, performance improved with the preservation of low-frequency fine-structure cues (EAS). This improvement decreased for continuous EAS sentences as more spectral channels were added, but increased as more channels were added to noise-interrupted EAS sentences. Performance was impaired more when high-CSE intervals were replaced by noise than when low-CSE intervals were replaced, but this pattern did not differ across listening modes. Utilizing information-bearing acoustic changes to understand speech is predicted to generalize to cochlear implant users who receive EAS inputs.