伴有进展为急性白血病的白血病前期1q三体。

Trisomy of 1q in preleukaemia with progression to acute leukaemia.

作者信息

Najfeld V, Singer J V, James M C, Fialkow P J

出版信息

Scand J Haematol. 1978 Jul;21(1):24-8. doi: 10.1111/j.1600-0609.1978.tb02491.x.

DOI:10.1111/j.1600-0609.1978.tb02491.x

Abstract

Marrow cells from an untreated man with preleukaemia were found to have trisomy for the long arm of chromosome 1 which was translocated to the end of the long arm of number 11, i.e., 46,XY, -11,+t (1:11) (q11 or q12; q25). The same abnormality was found in metaphases from 8 individual granulocytic colonies. With development of acute myelomonocytic leukaemia, in addition to the basic chromosome abnormality, trisomy of chromosome 8 and an extra chromosome number 19 with partial deletion were found. Fibroblasts grown from marrow biopsy material showed a normal diploid complement, 46,XY.

摘要

在一名未经治疗的患白血病前期男子的骨髓细胞中，发现其1号染色体长臂三体并易位至11号染色体长臂末端，即46，XY，-11，+t(1;11)(q11或q12;q25)。在8个独立的粒细胞集落的中期相中也发现了同样的异常。随着急性粒单核细胞白血病的发展，除了基本的染色体异常外，还发现了8号染色体三体以及一条额外的19号染色体且有部分缺失。从骨髓活检材料中培养出的成纤维细胞显示为正常二倍体核型，46，XY。