各种血液系统恶性肿瘤患者中1号染色体长臂的完全或部分三体性。

Complete or partial trisomy for the long arm of chromosome 1 in patients with various hematologic malignancies.

作者信息

Mamaeva S E, Mamaev N N, Jartseva N M, Belyaeva L V, Scherbakova E G

出版信息

Hum Genet. 1983;63(2):107-12. doi: 10.1007/BF00291527.

DOI:10.1007/BF00291527

Abstract

This study contains data obtained from a cytogenetic investigation of six patients with acute and chronic leukaemia. The karyotypes of bone marrow or blood cells of these patients showed a partial or complete trisomy for the long arm of chromosome 1. Three observations revealed a pronounced resistance of cell clones with 1q+ towards cytostatic therapy, and a comparatively short life span of patients after detection of 1q+. The importance of these changes for the role of some chromosomes and chromosome loci in leukaemogenesis is discussed.

摘要

本研究包含了对6例急慢性白血病患者进行细胞遗传学调查所获得的数据。这些患者骨髓或血细胞的核型显示1号染色体长臂存在部分或完全三体性。三项观察结果表明，携带1q+的细胞克隆对细胞抑制疗法具有显著抗性，且在检测到1q+后患者的生存期相对较短。本文讨论了这些变化对于某些染色体和染色体位点在白血病发生过程中作用的重要性。

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