达尔文来到诊所。

Darwin Comes to Clinic.

机构信息

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.

出版信息

Trends Genet. 2017 Jan;33(1):1-2. doi: 10.1016/j.tig.2016.11.005. Epub 2016 Nov 28.

DOI:10.1016/j.tig.2016.11.005

Abstract

What might be the benefits of whole-genome rather than whole-exome sequencing (WES) for identifying the genetic causes of human disabilities? A recent paper by Doan et al. focuses attention on mutations in human accelerated regions (HARs), a subset of genomic regulatory elements showing accelerated evolution between chimpanzees and humans.

摘要

全基因组测序而非外显子组测序（WES）用于识别人类残疾的遗传原因可能有哪些好处？Doan 等人最近的一篇论文关注了人类加速区（HARs）中的突变，HARs 是基因组调控元件的一个子集，在黑猩猩和人类之间的进化过程中加速。