Honzlová M, Pelisková Z, Trnavský K
Cas Lek Cesk. 1989 Jan 27;128(5):149-52.
The purpose was to assemble experience with the treatment of rheumatoid arthritis with fish oil and to compare the results with reports from abroad. The investigated group comprised 10 women who suffered from confirmed RA. The patients were treated by nonsteroid antirheumatic drugs. During the trial processed fish oil [Martens'oil], 10 g/day was added. The tolerance of the preparation was good. The investigation period lasted three months. After one-month intervals laboratory and clinical indicators of the activity of the disease were investigated and compared with baseline values before treatment. All investigated values improved, however, only some significantly: the level of C-reactive proteon, pain on movement, the articular index, morning stiffness. The latex-fixation test was in all patients positive at the beginning and at the end of the investigation. Fish oil as a dietetic supplement of treatment with non-steroid anti-rheumatic drugs gives the patients subjective relief, the results of preliminary observations indicate the necessity of further, in particular double blind trials.
目的是积累使用鱼油治疗类风湿性关节炎的经验,并将结果与国外的报告进行比较。研究组包括10名确诊为类风湿性关节炎的女性患者。患者接受非甾体类抗风湿药物治疗。在试验过程中,添加了加工过的鱼油(马滕斯油),每天10克。制剂的耐受性良好。研究期持续三个月。每隔一个月对疾病活动的实验室和临床指标进行调查,并与治疗前的基线值进行比较。所有调查值均有所改善,但只有一些有显著改善:C反应蛋白水平、运动疼痛、关节指数、晨僵。在研究开始和结束时,所有患者的乳胶凝集试验均为阳性。鱼油作为非甾体类抗风湿药物治疗的饮食补充剂可使患者主观上得到缓解,初步观察结果表明有必要进行进一步研究,特别是双盲试验。