Eyckmans Jeroen, Chen Christopher S
Department of Biomedical Engineering and the Biological Design Center, Boston University, Boston, MA 02215, USA
The Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
J Cell Sci. 2017 Jan 1;130(1):63-70. doi: 10.1242/jcs.198630. Epub 2016 Dec 1.
Cells dynamically assemble and organize into complex tissues during development, and the resulting three-dimensional (3D) arrangement of cells and their surrounding extracellular matrix in turn feeds back to regulate cell and tissue function. Recent advances in engineered cultures of cells to model 3D tissues or organoids have begun to capture this dynamic reciprocity between form and function. Here, we describe the underlying principles that have advanced the field, focusing in particular on recent progress in using mechanical constraints to recapitulate the structure and function of musculoskeletal tissues.
在发育过程中，细胞动态组装并组织成复杂的组织，而细胞及其周围细胞外基质的三维（3D）排列反过来又反馈调节细胞和组织功能。用于模拟3D组织或类器官的细胞工程培养的最新进展已开始捕捉这种形式与功能之间的动态相互作用。在这里，我们描述了推动该领域发展的基本原理，特别关注利用机械约束来重现肌肉骨骼组织的结构和功能方面的最新进展。
