Staiger J F, Nürnberger F
Department of Anatomy and Cytobiology, Justus Liebig University, Giessen, Federal Republic of Germany.
Cell Tissue Res. 1989 Sep;257(3):471-90. doi: 10.1007/BF00221457.
The septal region represents an important telencephalic center integrating neuronal activity of cortical areas with autonomous processes. To support the functional analysis of this brain area in the guinea pig, the afferent connections to the lateral septal nucleus were investigated by the use of iontophoretically applied horseradish peroxidase (HRP). Retrogradely labeled perikarya were located in telencephalic, diencephalic, mesencephalic and metencephalic sites. The subnuclei of the lateral septum (pars dorsalis, intermedia, ventralis, posterior) receive afferents from the (i) medial septal nucleus, diagonal band of Broca (pars horizontalis and pars ventralis), and the principal nucleus of the stria terminalis, the hippocampus, and amygdala (nucleus medialis): (ii) the medial habenular nucleus, and the para- (peri-) ventricular, parataenial and reuniens nuclei of the thalamus; the anterior, lateral and posterior hypothalamic areas (in particular, the medial and lateral preoptic, suprachiasmatic, periventricular, paraventricular, arcuate, premammillary, and supramammillary nuclei; (iii) the periaquaeductal grey, ventral tegmental area, nucleus interfascicularis, nucleus reticularis linearis, central linear nucleus, interpeduncular nucleus; (iv) dorsal and medial raphe complex, and locus coeruleus. Each subnucleus of the lateral septum displays an individual, differing pattern of afferents from the above-described regions. Based on a double-labeling method, the vasopressinergic and serotonergic afferents to the lateral septum were found to originate in the nucleus paraventricularis hypothalami and the raphe nuclei, respectively.
隔区是一个重要的端脑中枢，可整合皮质区域的神经元活动与自主过程。为支持对豚鼠该脑区的功能分析，采用离子电渗法应用辣根过氧化物酶（HRP）研究了外侧隔核的传入连接。逆行标记的神经元胞体位于端脑、间脑、中脑和后脑部位。外侧隔的亚核（背侧部、中间部、腹侧部、后部）接受来自以下部位的传入纤维：（i）内侧隔核、布罗卡斜角带（水平部和腹侧部）、终纹床核、海马和杏仁核（内侧核）；（ii）内侧缰核以及丘脑的室旁、旁室旁、室旁和连合核；下丘脑前区、外侧区和后区（特别是内侧和外侧视前核、视交叉上核、室周核、室旁核、弓状核、乳头前核和乳头体上核）；（iii）导水管周围灰质、腹侧被盖区、束间核、线性网状核、中央线性核、脚间核；（iv）背侧和内侧中缝核复合体以及蓝斑。外侧隔的每个亚核都显示出来自上述区域的独特的、不同的传入纤维模式。基于双重标记法，发现外侧隔的加压素能和5-羟色胺能传入纤维分别起源于下丘脑室旁核和中缝核。
