Frycová H, Metys J
Cesk Farm. 1989 Jul;38(6):264-8.
Pipethiadene, a prophylactic of vasomotoric headaches of the series of 4,9-dihydrothieno(2,3-c)-2-benzothiepine derivatives, shows a peripheralpharmacological profile of an antiallergic agent. The experiments in rats showed a high antianaphylactic effect of pipethiadene in the passive cutaneous anaphylaxis (PCA) test. Pipethiadene also exerted intensive antianaphylactoid action in rats on the liberator of histamine, compound 48/80, on dextran, and in the use of a combination of ovalbumin with indomethacin. In comparative pharmacological experiments with pizotifen and cyproheptadine an attempt was made to estimate the relative role of histamine and 5-hydroxytryptamine 5-HT) mediators in the employed experimental procedures in rats.
哌替噻吨，一种4,9-二氢噻吩并(2,3-c)-2-苯并硫氮杂䓬系列血管运动性头痛预防药，具有抗组胺药的外周药理学特征。大鼠实验表明，哌替噻吨在被动皮肤过敏反应（PCA）试验中具有高度抗过敏作用。哌替噻吨对组胺释放剂48/80、右旋糖酐以及在使用卵清蛋白与吲哚美辛组合时，对大鼠也发挥了强烈的抗类过敏作用。在用匹莫齐特和赛庚啶进行的比较药理学实验中，试图评估组胺和5-羟色胺（5-HT）介质在大鼠所采用实验程序中的相对作用。
