Icelo-Ávila Estefanía, Amador-Sánchez Yoarhy A, Polindara-García Luis A, Miranda Luis D
Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, 04510, México, D.F., México.
Org Biomol Chem. 2017 Jan 4;15(2):360-372. doi: 10.1039/c6ob02266a.
A synthetic approach to the 6-methyl-3,4-dihydropyrazinone core from Ugi adducts is described. This methodology relies on the regioselective C-N bond formation between an allenamide moiety at C-β and an amide anion formed under base-mediated conditions. This protocol allows easy access to tricyclic systems such as pyrazino[2,1-a]isoindole and pyrazino[2,1-a]isoquinoline nuclei.
描述了一种从乌吉加合物合成6-甲基-3,4-二氢吡嗪酮核心的方法。该方法依赖于在碱介导条件下，C-β位的烯丙酰胺部分与形成的酰胺阴离子之间区域选择性地形成C-N键。此方案能够轻松合成三环体系，如吡嗪并[2,1-a]异吲哚和吡嗪并[2,1-a]异喹啉核。
