Chien Tsai-Ju, Liu Chia-Yu, Lu Ruey-Hwa, Kuo Chin-Wei, Lin Yang-Chao, Hsu Chung-Hua
Institute of Traditional Medicine, National Yang-Ming University, Taipei, Taiwan; Division of Hemato-Oncology, Department of Internal Medicine, Branch of Zhong-xing, Taipei City Hospital, Taipei, Taiwan.
Institute of Traditional Medicine, National Yang-Ming University, Taipei, Taiwan; Branch of Linsen and Chinese Medicine, Taipei City Hospital, Taipei, Taiwan; Taiwan International Traditional Chinese Medicine Training Center, Taiwan.
Complement Ther Med. 2016 Dec;29:204-212. doi: 10.1016/j.ctim.2016.10.001. Epub 2016 Oct 20.
Traditional Chinese Medicine (TCM) has been used increasingly as complementary medicine in cancer care. Kuan-Sin-Yin (KSY) is a TCM decoction containing seven herbs known to cause immunomodulation or anticancer activity, and which are associated with the TCM concept of Qi and energy supply. Kuan-Sin-Yin has cytostatic effects on cancer cells in animal models.
The aim of this study is to evaluate the level of improvement in meridian energy and heart-rate variability (HRV) and to assess whether these observations are compatible with TCM theory.
A non-randomized controlled trial was designed with monitoring of the meridian electro-conductivity and heart-rate variability (HRV) to compare the efficacy of Kuan-Sin-Yin in the control and experimental groups. 52 patients were enrolled in this study. We also measured cancer-related symptoms and quality of life as secondary outcomes.
We found that colon cancer patients who received KSY as complementary therapy benefitted with enhancement of meridian energy (Yin meridian: 27.90:35.45μA; p=0.014; Yang meridian: 27.09:33.55μA; p=0.024) and increases in HRV activity (78.40:129.04ms; SDNN: p=0.001) and parasympathetic tone(HF:1644.80:3217.92 ms; p=0.003; RMMSD:99.76:164.52ms; p=0.002). Cancer-related symptoms decreased (ECOG>1:46.2:7.7%; p=0.0001), and quality of life (KSY group: PCS 35.46:42.12, p=0.0001; MCS: 44.50:47.55, p=0.209) was improved with statistical significance.
The correlation of positive results reflected in meridian energy and HRV activity confirms the positive role of complementary medicine of Kuan-Sin-Yin in cancer care.
中医作为癌症治疗中的补充医学应用日益广泛。宽心饮（KSY）是一种中药汤剂，由七种已知具有免疫调节或抗癌活性的草药组成，与中医的气和能量供应概念相关。宽心饮在动物模型中对癌细胞有抑制作用。
本研究旨在评估经络能量和心率变异性（HRV）的改善程度，并评估这些观察结果是否与中医理论相符。
设计了一项非随机对照试验，监测经络电导率和心率变异性（HRV），以比较宽心饮在对照组和实验组中的疗效。本研究共纳入52例患者。我们还将癌症相关症状和生活质量作为次要结局进行了测量。
我们发现，接受宽心饮作为辅助治疗的结肠癌患者，经络能量增强（阴经：27.90:35.45μA；p = 0.014；阳经：27.09:33.55μA；p = 0.024）、HRV活性增加（78.40:129.04ms；SDNN：p = 0.001）以及副交感神经张力增加（HF：1644.80:3217.92ms；p = 0.003；RMMSD：99.76:164.52ms；p = 0.002），从中受益。癌症相关症状减少（ECOG>1：46.2:7.7%；p = 0.0001），生活质量（宽心饮组：PCS 35.46:42.12，p = 0.0001；MCS：44.50:47.55，p = 0.209）有统计学意义的改善。
经络能量和HRV活性反映出的阳性结果之间的相关性证实了宽心饮辅助医学在癌症治疗中的积极作用。
