More R C, Kody M H, Kabo J M, Dorey F J, Meals R A
Wadsworth Veterans Administration Medical Center, Orthopaedic Research, Los Angeles, CA 90073.
Clin Orthop Relat Res. 1989 Oct(247):306-12.
Using a rabbit distal tibia fracture model treated by immobilization for three weeks, the effects of two nonsteroidal antiinflammatory drugs on postfracture limb swelling, joint stiffness, and torsional bone strength were examined. Limb swelling in rabbits treated with low-dose piroxicam was reduced by 39%, and high-dose piroxicam reduced limb swelling by 86%. Flunixin, tested at one dose, reduced swelling by 53%. Neither piroxicam nor flunixin affected ankle stiffness or tibia torsional strength.
利用兔胫骨远端骨折模型，通过固定三周进行治疗，研究了两种非甾体抗炎药对骨折后肢体肿胀、关节僵硬和扭转骨强度的影响。低剂量吡罗昔康治疗的兔肢体肿胀减少了39%，高剂量吡罗昔康使肢体肿胀减少了86%。氟尼辛以单一剂量进行测试，肿胀减少了53%。吡罗昔康和氟尼辛均未影响踝关节僵硬程度或胫骨扭转强度。
